19. Mortality rate in young adults with intracranical hemorrhage and prognostic factors

Mai Duy Ton, Nguyen Tien Dung

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Abstract

Hemorrhagic stroke in young patients has a significant mortality rate. In Vietnam, there is limited data on the outcome of this group of patients. This study aimed to  explore the mortality rate and some factors related to 90th-day death among young ICH patients. A cross-sectional retrospective study was conducted at Bach Mai stroke center from November 2020 to May 2022. Multivariate regression logistics was used to  interpret the mortality predictors after 90 days. 212 patients were recruited. The mortality rate was 28.8%. Predictors of 90-day mortality include lower Glasgow coma score at admission (with OR 0.623 for each additional GCS; 95%CI: 0.40 - 0.96; p = 0.034), bleeding in the brain stem (OR 7.65; 95%CI: 1,70 - 34.4; p = 0.008) and higher hematoma volume (OR 1.22 for each 10mL increase in volume; 95%CI: 1.03 - 1.43; p = 0.019).

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References

1. Sacco RL, Kasner SE, Broderick JP, et al. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013; 44(7):2064-2089. doi:10.1161/STR.0b013e318296aeca.
2. Hemphill JC 3rd, Greenberg SM, Anderson CS, et al. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2015; 46(7):2032-2060. doi:10.1161/STR.0000000000000069.
3. Koivunen RJ, Satopää J, Meretoja A, et al. Incidence, risk factors, etiology, severity and short-term outcome of non-traumatic intracerebral hemorrhage in young adults. Eur J Neurol. 2015; 22(1): 123-132. doi:10.1111/ene.12543.
4. Lai SL, Chen ST, Lee TH, Ro LS, Hsu SP. Spontaneous intracerebral hemorrhage in young adults. Eur J Neurol. 2005; 12(4): 310-316. doi:10.1111/j.1468-1331.2004.00957.x.
5. Tatlisumak T, Cucchiara B, Kuroda S, Kasner SE, Putaala J. Nontraumatic intracerebral haemorrhage in young adults. Nat Rev Neurol. 2018; 14(4): 237-250. doi:10.1038/nrneurol.2018.17.
6. Hemphill JC, Greenberg SM, Anderson CS, et al. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2015; 46(7): 2032-2060. doi:10.1161/STR.0000000000000069.
7. Kalita J, Goyal G, Kumar P, Misra UK. Intracerebral hemorrhage in young patients from a tertiary neurology center in North India. J Neurol Sci. 2014; 336(1-2): 42-47. doi:10.1016/j.jns.2013.09.037.
8. Bevan H, Sharma K, Bradley W. Stroke in young adults. Stroke. 1990; 21(3): 382-386. doi:10.1161/01.str.21.3.382.
9. Fuh JL, Liu HC, Wang SJ, Lo YK, Lee LS. Nontraumatic hemorrhagic stroke in young adults in taiwan. J Stroke Cerebrovasc Dis. 1994; 4(2): 101-105. doi:10.1016/S1052-3057(10)80117-X.
10. Feigin VL, Brainin M, Norrving B, et al. World Stroke Organization (WSO): Global Stroke Fact Sheet 2022. Int J Stroke. 2022; 17(1): 18-29. doi:10.1177/17474930211065917.
11. Awada A, Daif A, Obeid T, Al Rajeh S. Nontraumatic cerebral hemorrhage in the young: a study of 107 cases. J Stroke Cerebrovasc Dis. 1998; 7(3): 200-204. doi:10.1016/s1052-3057(98)80008-6.
12. Greenberg SM, Ziai WC, Cordonnier C, et al. 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2022; 53(7): e282-e361. doi:10.1161/STR.0000000000000407.