31. Analgesic effects of ich phu dan capsules in experimental animals

Abstract

Ich phu dan capsules are intended to treat menstrual pain. The study aimed to assess the analgesic effects of Ich phu dan capsules in animal models. Three animal models were used: a hot plate, tail flick and acetic acid-induced writhing test. Mice were divided into four groups and were given orally: group 1 distilled water; group 2 control drug (codeine phosphate in hot plate and tail flick tests or aspirin in writhing test); groups 3 and 4: Ich phu dan at the doses of 1.44 capsules (approx 521.1 mg dried extract) or 2.88 capsules (approx 1042.2 mg dried extract)/kg b.w/day, respectively. The results showed that Ich phu dan capsules at both doses increased the mice’s reaction time in hot plate and tail flick models and decreased the number of acetic acid-induced writhing movements in mice. There was no statistically significant difference between the two doses of Ich phu dan capsules. In conclusions, Ich phu dan capsules at the doses of 1.44 capsules (approx 521.1 mg dried extract) and 2.88 capsules (approx 1042.2 mg dried extract)/kg b.w/day showed significant analgesic effect in animal models.