6. Evaluation of early mortality in patients with advanced HIV disease in Vietnam using glomerular filtration rate estimated with MDRD equation
Main Article Content
Abstract
According to the recommendations, if the creatinine test is routinely available, physicians should use the estimated glomerular filtration rate at baseline before initiating TDF regimens. In this retrospective observational cohort study. We enrolled patients of 18 years old and above, diagnosed with advanced HIV diseases between January 2021 to May 2022, from all ART clinics in 15 provinces in Vietnam. Renal function was assessed by the estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease (MDRD) equation. 6.0% (108/1787) had baseline eGFR < 60 ml/min/1.73m2. Factors associated with baseline renal impairment (eGFR < 60 ml/min/1.73m2) were gender (female) (OR = 4.07, 95%CI: 2.71 - 6.08), low hemoglobin (OR = 1.86, 95%CI: 1.01 - 3.22) and older age (OR = 1.07, 95%CI: 1.05 - 1.09). Mortality in patients with renal impairment at baseline was 11.5% (7/61), while the normal renal function group was 7.5% (99/1362). There is a need for assessment of renal function at baseline before ART initiation and regular monitoring of renal function for patients with HIV during follow-up.
Article Details
Keywords
glomerular filtration rate, HIV, chronic kidney disease, advanced HIV, diseases
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