Evaluation protective effect of “da day an chau” tablets in rats induced gastroesophageal reflux disease model
Main Article Content
Abstract
Research was conducted to evaluate the esophageal protective effects of "Da day An Chau" Tablet (DDAC) on experimental rats with induced gastroesophageal reflux disease model. Wistar rats, randomly divided into 5 groups, of 10 animals each: control group, GERD model group, positive control group (esmeprazole), DDAC with dose of 0.58 g/kg/day and 1.74 g/kg/day for 15 consecutive days. Rats were ligated between the forestomach and corpus and the pyloric portion combined with previous ingestion of indomethacin at 40 mg/kg to induce gastroesophageal reflux disease. The evaluation indicators are gastric juice volume, gastric juice pH, gastric acidity, lesion area, and esophageal index. Research results show that DDAC at both doses of 0.58 g/kg/day and 1.74 g/kg/day protects the esophagus by reducing gastric juice volume, increasing gastric pH, reducing total acidity and free acidity, reduced lesion area and esophageal index compared to the GERD model group.
Article Details
Keywords
Da day An Chau, gastroesophageal reflux disease, Wistar rats
References
2. Eusebi LH, Ratnakumaran R, Yuan Y et al. Global prevalence of, and risk factors for, gastro - oesophageal reflux symptoms: a meta-analysis. Gut 2018. 2018;67(3):430-440.
3. Quach Trong Duc, Ho Xuan Linh. The role of GERDQ questionaire in the diagnosis of gastro-esophageal reflux disease with esophageal syndrome. Y Hoc TP Ho Chi Minh. 2012; Vol. 16-Supplement of No 1:15-22.
4.Hosseinkhani A, Lankarani KB, Mohagheghzadeh A, Long C, Pasalar M. An Evidence-based Review of Medicinal Herbs for the Treatment of Gastroesophageal Reflux Disease (GERD. Current drug discovery technologies. 2018;15(4):305-314.
5. Do Tat Loi. Vietnamese medicinal plants and herbs. In: Hong Duc Publishing House; 2005:481-482.
6. Do Huy Bich et al. Medicinal plants and medicinal animals in Vietnam. In: Vol 1. Hanoi Science and Technology Publishing House; 2006:141-143.
7. Ministry of health. Vietnam Pharmacopoeia. In: Vol 2. Medical Publishing House; 2018:1243-1244.
8. Huynh Tan Hoi. H. Pylori bacteria – cause of peptic ulcer and some treatments. Journal of Critical Reviews. 2020;7(14):887-890.
9. Aziz M. A, Habib M. R, Karim M. R. Antibacterial and Cytotoxic Activities of Hedychium coronarium J. Koenig. Research Journal of Agriculture and Biological Sciences. 2009;5(6):969-972.
10. Suresh G, Reddy P. P, Babu K.S. Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium. Bioorganic & amp; Medicinal Chemistry Letters. 2010; 20:7544-7548.
11. Shrotriya, S., M.S. Ali, A. Saha, S.C. Bachar and, M.S. Islam. Anti-inflammatory and analgesic effects of Hedychium coronarium Koen. Pak J Pharm. 2007;20(1):47-51.
12. Hua Hongping. An article for the treatment of psoriasis according to traditional Chinese medicine. Licensed by the State Intellectual Property office of the People’s Republic of China (2/4/ 2015). Published online 2015.
13. Shyam Sundar Gupta, Lubna Azmi, P. K. Mohapatra et al. Flavonoids from whole Plant of Euphorbia hirta and their Evaluation against Experimentally induced Gastroesophageal Reflux Disease in Rats. Pharmacognosy Magazine. 2017;3(49):127-134.
14. Joni Sharma, Shyam Sundar Gupta, B Pavan Kumar et al. Effect of Usnic acid and Cladonia Furcata extract on gastroesophageal reflux disease in rats. International Journal of Experimental Pharmacology. 2014;4(1):55-60.
15. Peter J. Kahrilas. GERD pathogenesis, pathophysiology, and clinical manifestations. Cleveland Clinic Journal of Medicine. 2003;70:4-19.
16. Rao CV, Vijayakumar M. Effect of quercetin, flavonoids and alpha-tocopherol an antioxidant vitamin on experimental reflux oesophagitis in rats. Eur J Pharmacol. 2008;589:233-238.