30. Ung thư biểu mô tế bào vảy dạng lympho - biểu mô: Báo cáo ca bệnh và xem xét tài liệu liên quan

Abstract

The WHO classification of lung tumors from 2015 was updated in 2021 where squamous cell carcinoma (SCC) has some changes/additions compared to the previous classification. Basically, SCC is divided into 2 groups: (1) Pre-invasive lesions; and (2) Squamous cell carcinoma. Group (1) includes squamous epithelial dysplasia and squamous cell carcinoma in situ. Squamous epithelial dysplasia is a benign lesion with some histological abnormalities; Squamous cell carcinoma in situ is considered a pre-invasive lesion. Group (2) includes squamous cell carcinoma (SCC) and lymphoepithelial carcinoma (LEC). LEC is a subtype migrated from lymphoma (in the old classification), added to this classification. In clinical practice of lung cancer, SCC is quite common and can appear in many different organs; but LECs are extremely rare. LEC is an uncommon type of cancer. They are commonly found in the pharynx and excretory glands of organs such as the salivary glands, thymus, stomach, and liver. However, recent cases of LEC detected in other anatomic sites are also reported, such as bladder, lacrimal gland, ovary, cervix, skin, etc. Since the first case was reported on lung LEC by Begin et al (1987), to our knowledge there have been more than 150 reported cases of pulmonary LEC in the literature worldwide. We present a case of LEC with lung parenchymal tumor presentation with imaging features very similar to a benign lung tumor with abscess. Preoperative diagnosis is difficult. The patient underwent laparoscopic resection of the lung containing the tumor. Histopathological diagnosis and immunohistochemistry of postoperative specimens confirmed LEC case.