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Published: 2023-02-28
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DOI: https://doi.org/10.52852/tcncyh.v163i2.1449
Issue
Vol. 163 No. 2 (2023)
Section
Các bài báo
How to Cite
Hà, N. T. H. ., Tuấn, P. L. A. ., Tâm, N. T. ., Lan, N. N. ., Thắm, H. H. ., Văn, T. T. ., & Khánh, T. V. . (2023). 7. Identification of sars-cov-2 variants in patients during the 2021 covid-19 wave in Bac Giang by next generation sequencing. Journal of Medical Research, 163(2), 55-62. https://doi.org/10.52852/tcncyh.v163i2.1449

7. Identification of sars-cov-2 variants in patients during the 2021 covid-19 wave in Bac Giang by next generation sequencing

Nguyen Thi Hai Ha, Pham Le Anh Tuan, Nguyen Thi Tam, Nguyen Ngoc Lan, Hoang Hong Tham, Ta Thanh Van, Tran Van Khanh

Main Article Content

Abstract

The coronavirus disease of 2019 (COVID-19) pandemic caused by SARS-CoV-2 is a global threat and has severe impact on social and economic in Vietnam and around the world. The identification of circulating SARS-CoV-2 variants has important implications in monitoring the evolution of the virus, contributing to the promotion of vaccine research and diagnostic biologicals. This study was carried out on 38 patients diagnosed positive for SARS-CoV-2 from the industrial zones in Bac Giang province to identify SARS-CoV-2 variants and specific mutations in the genome viruses by next-generation sequencing (NGS). The mean age of participants in the study was 40.77 ± 14.63. Research results have detected all 38 samples of SARS-CoV-2 virus belonging to the Delta variant, identified 16 mutations appearing in all patient samples, and 27 specific changes appearing only in some samples in the same period. There are 3 mutations on structural genes including S: Leu5Phe, Pro819Ser, and His1101Tyr.

Article Details

Keywords

SARS-CoV-2, NGS, mutation

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