1. Tác dụng bảo vệ gan, chống oxy hóa của viên nén BogaTN trên thực nghiệm

Abstract

The study aimed to evaluate the hepatoprotective and antioxidant activities of BogaTN tablets in experimental mice. Mice were divided randomly into 5 groups of ten mice per cage: control, model, positive control (silymarine), BogaTN at the dose of 1.55 g/kg/day and BogaTN at the dose of 4.64 g/kg/day. Mice were orally given an administration of the researched products and distilled water during 8 consecutive days. On the 8^th day, after 2 hours of oral administration, mice at group 2, 3, 4, 5 were given an oral administration of paracetamol 400 mg/kg in order to induce liver cell damage. 48 hours later, all indexes including AST, ALT, GGT levels, albumin, total bilirubin concentration, liver MDA (malondialdehyd) concentration, macroscopic and microscopic analyses of livers were evaluated. As a result, BogaTN at both doses posed the hepatoprotective effect on paracetamol-induced liver injury through the decrease of AST, ALT, GGT levels as compared with the model group, an increase of albumin concentration, a slight decrease of total bilirubin concentration and an improvement of liver histopathology as compared with the model group.