3. The role of vindr artificial intelligence in projecting the malignant risk of solitary pulmonary nodules

Le Hoan, Le Tuan Linh, Dinh Thi Thanh Hong, Nguyen Thi Nhu Quynh, Le Minh Hang

Main Article Content

Abstract

Solitary pulmonary nodule was defined as well-circumscribed round lesion measuring up to 3 cm in diameter and surrounded by aerated lung without pulmonary collapse, mediastinal lymph nodes or pleural effusion. This is a common pulmonary lesion, which can have many causes. Benign causes include: tuberculoma, harmatoma, pulmonary lymph nodes, sarcoidosis, aspergilloma. Malignant etiologies include lung cancer, metastatic lung cancer, lymphoma, etc. Artificial intelligence in diagnosing isolated lung nodules aims at early detection of lesions, accurate diagnosis and prognosis of disease. Our study was conducted to evaluate the role of VinDr artificial intelligence application in predicting the individual risk of solitary pulmonary nodules in order to  assist clinicians  for acquiring additional means  for timely diagnosis and  provide appropriate treatment options for the patient. This is a  descriptive study  composed of 23 patients with isolated pulmonary nodules undergoing diagnostic transthoracic lung biopsy ; AI analysis results showed  a sensitivity of 83.3%, a specificity  of 100%, and a negative predictive value  of 62.5%. Moreover, there was a good consensus between AI analysis and histopathological results. In conclusion, our study suggests that AI has the potential to become an essential tool in predicting the malignant risk of Solitary pulmonary nodule - SPN. However, more research is needed to validate the use of AI in clinical practice, and a combination of AI and traditional methods is recommended for more accurate diagnosis and management of SPN.

Article Details

References

1. LS Seo JB, Yun J, et al. Deep Learning Applications in Chest Radiography and Computed Tomography: Current State of the ArtJ Thorac Imaging 2019; 34(2): 75 85 doi:10 1097/RTI 0000000000000387.
2. Huang P, Lin CT, Li Y, et al. Prediction of lung cancer risk at follow-up screening with low-dose CT: a training and validation study of a deep learning method. Lancet Digit Healt. 2019; 1(7): e353-e362.
3. S.k. L, Mohanty SN, K. S, N. A, Ramirez G. Optimal deep learning model for classification of lung cancer on CT images. Future Gener Comput Syst. 2019; 92: 374-382. doi:10.1016/j.future.2018.10.009.
4. Bi WL, Hosny A, Schabath MB, et al. Artificial intelligence in cancer imaging: Clinical challenges and applications. CA Cancer J Clin. 2019; 69(2): 127-157. doi:10.3322/caac.21552.
5. Trịnh Thị Hương. Nhận Xét Kết Quả Sinh Thiết Xuyên Thành Ngực Dưới Hướng Dẫn Chụp Cắt Lớp vi Tính Tổn Thương Nốt Phổi. Luận văn chuyên khoa cấp 2. Đại học Y Hà Nội; 2018.
6. Laurent F, Latrabe V, Vergier B, Montaudon M, Vernejoux JM, Dubrez J. CTguided transthoracic needle biopsy of pulmonary nodules smaller than 20 mm: results with an automated 20-gauge coaxial cutting needle. Clin Radiol. 2000; 55(4): 281-287. doi:10.1053/crad.1999.0368.
7. Lung Cancer Survival Rates | 5-Year Survival Rates for Lung Cancer. Accessed November 7, 2021. https://www.cancer.org/cancer/lung-cancer/detection-diagnosis-staging/survival-rates.html.
8. Tandon YK, Bartholmai BJ, Koo CW. Putting artificial intelligence (AI) on the spot: machine learning evaluation of pulmonary nodules. J Thorac Dis. 2020; 12(11). doi:10.21037/jtd-2019-cptn-03.
9. Onishi Y, Teramoto A, Tsujimoto M, et al. Multiplanar analysis for pulmonary nodule classification in CT images using deep convolutional neural network and generative adversarial networks. Int J Comput Assist Radiol Surg. 2020; 15(1): 173-178. doi:10.1007/s11548-019-02092-z.
10. Chen K, Nie Y, Park S, et al. Development and Validation of Machine Learning–based Model for the Prediction of Malignancy in Multiple Pulmonary Nodules: Analysis from Multicentric Cohorts. Clin Cancer Res. 2021; 27(8): 2255-2265. doi:10.1158/1078-0432.CCR-20-4007.
11. Massion PP, Antic S, Ather S, et al. Assessing the Accuracy of a Deep Learning Method to Risk Stratify Indeterminate Pulmonary Nodules. Am J Respir Crit Care Med. 2020; 202(2): 241-249. doi:10.1164/rccm.201903-0505OC.