23. The Role of 18F-FDG PET/CT in diagnosis for non-small cell lung cancer at National Cancer Hospital
Main Article Content
Abstract
This study aimed to assess the role of PET/CT in staging for non-small cell lung cancer at the National cancer hospital. The distant metastastic frequencies detected by PET/CT were significantly higherthan by conventional methods. The percentages of detection in bone, adrenal gland, contralateral lung, pleura by conventional methods and by PET/CT were 20.1%; 5.8%; 13.6%; 1.5% and 25%; 11.7%; 7.4%; 9.7%, respectively. PET/CT did not detect any brain metastasis in all 9 cases although MRI did show evidence of metastasis. Cancer staging was changed in 34% of patients, in which understaging accounted for 22.8%, and overstaging accounted for 11.2%. After PET/CT, the treatment strategy was modified accordingly. We suggest that PET/CT should be included in the diagnostic work-up of patients with lung cancer, since it provides useful information to select appropriate cancer treatment.
Article Details
Keywords
non-small cell lung cancer, PET/CT, lung-cancer staging
References
2. Goldstraw P, Chansky K, et al. The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer. J Thorac Oncol. 2016;11:39.
3. Alzahouri K, Velten M, Arveux P, et al. Management of SPN in France. Pathways for definitive diagnosis of solitary pulmonary nodule: a multicentre study in 18 French districts. BMC Cancer. 2008;8:93.
4. Hochhegger B, Alves GR, Irion KL et al. PET/CT imaging in lung cancer: indications and findings. J Bras Pneumol. 2015;41(3):264-274.
5. Tira Bunyaviroch, R. Edward Coleman. PET Evaluation of Lung Cancer. The journal of nuclear medicine. 2006;47(3):451-469.
6. Songa JW, Oha YM, Shima TS, et al. Efficacy Comparison Between 18F-FDG PET/CT and Bone Scintigraphy in Detecting Bony Metastases of Non-Small-Cell Lung Cancer. Lung Cancer. 2009;65(3):257-390.
7. Tomohiro Tamura, Koichi Kurishima, et al. Specific organ metastasis and survival in metastatic non-small-cell lung cancer. Mol Clin Oncol. 2015;3(1):217-221.
8. Purandare N.C, Rangarajan V. Imaging of lung cancer: Implications on staging and management. Indian J Radiol Imaging. 2015;25(2):109-20.
9. Nguyễn Xuân Cảnh. Đặc điểm của ung thư phổi không tế bào nhỏ trên hình ảnh PET/CT với 18-FDG. Tạp chí Y học TP. Hồ Chí Minh. 2019;23(3).
10. Michael K. Gould, Jessica Donington, et al. Evaluation of Individuals With Pulmonary Nodules: When Is It Lung Cancer? Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2013 May;143(5):e93S-e120S. doi: 10.1378/chest.12-2351.
11. Yajuan Sun Hongjuan Yu, Jingquan Ma, et al. The Role of 18F-FDG PET/CT Integrated Imaging in Distinguishing Malignant from Benign Pleural Effusion. Plos one Published. August 25, 2016. doi: 10.1371/journal.pone.0161764.
12. Emine Budak, Gürsel Çok, Ayşegül Akgün. The Contribution of Fluorine 18F-FDG PET/CT to Lung Cancer Diagnosis, Staging and reatment Planning. Mol Imaging Radionucl Ther. 2018;27(2):73-80.
13. Viney R C, Michael J B, Madeleine T K. Randomized controlled trial of the role of positron emission tomography in the management of stage I and II NSCLC. J Clin Oncol. 2009 Jun 15;22(12):2357-62.
14. Mai Trọng Khoa, Trần Hải Bình. Giá trị của PET/CT trong chẩn đoán ung thư phổi không tế bào nhỏ. Tạp chí Ung thư học Việt Nam. 2011;101(8).
15. Emine Budak, Gürsel Çok, Ayşegül Akgün. The Contribution of Fluorine 18F-FDG PET/CT to Lung Cancer Diagnosis, Staging and reatment Planning. Mol Imaging Radionucl Ther. 2018 Jun;27(2):73-80.
16. Đặng Duy Cường. Đánh giá vai trò của PET/CT trong chẩn đoán giai đoạn ung thư phổi không tế bào nhỏ. Luận văn thạc sỹ Y học. Học viện Quân y. 2017.