Study on modification of lp-pla2, apo a-i, apo b, ratio apo b / apo a-i in serum in patients with coronary artery disease
Main Article Content
Abstract
Lipoprotein-associated phospholipase A2, apolipoprotein A-I, and apolipoprotein B have been shown to be involved in the formation of atherosclerotic plaques in coronary artery disease. Other way, the apo B/apo A-I ratio also shows a balance between the atherosclerotic apo B-rich cholesterol particles and the anti-atherosclerotic apo A-I cholesterol particles. Study on the modification of concentrations of Lp-PLA2, apo AI, apo B, the ratio of apo B/apo AI in serum in 105 subjects with coronary artery disease, degree of coronary stenosis ≥ 50% (disease group) and 110 control. Results: The patient group had higher concentrations of Lp-PLA2, apoB, apo B/apo A-I ratio than the control group, but the apo A-I concentration was lower than the control group (p <0.001). The combination of Lp-PLA2, apo A-I and apo B gave the best value in diagnosing the severity of coronary artery disease was 0.986, sensitivity 98.1%, specificity 90.9%. Therefore, Lp-PLA2, apo A-I, apo B concentrations may be of high value in the early prediction of atherosclerosis risk and in diagnosing the severity of coronary artery disease.
Article Details
Keywords
Lipoprotein-associated phospholipase A2 (Lp-PLA2), apolipoprotein A-I (apo A-I), apolipoprotein B (apo B), apo B/apo A-I ratio, coronary artery disease (CAD)
References
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