26. Value of serum concentration of Procalcitonin and C-reactive protein in diagnosis of bacteriological conditions with acute exacerbation of chronic obstructive
Main Article Content
Abstract
This study was performed to assess the value of PCT and CRP serum concentration in 123 patients diagnosed with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with infection (patient group) and 77 patients with acute exacerbation of chronic obstructive pulmonary disease without infection (control group) at the National Lung Hospital from July 2021 to June 2022. Results: The patient group had higher serum concentrations of PCT and CRP than the control group, at 7.30 ± 23.54 ng/ml, 76.70 ± 57.06 mg/l compare to 0.07 ± 0.12 ng/ml; 10.05 ± 10.85 mg/l with p < 0.01, p < 0.001, respectively. The cut-off CRP serum concentration in of infectious AECOPD was 15.5 mg/l, the sensitivity was 82.11%, the specificity was 90.90% with an AUC of 0.948. The cut-off PCT serum concentration of infectious AECOPD was 0.065 ng/ml, the sensitivity was 89.43%, and the specificity was 82.81% with an AUC of 0.937.
Article Details
Keywords
PCT, CRP, AECOPD
References
2. GOLD. Global Strategy for the Diagnosis, Management and Prevention of Obstructive Pulmonary Disease.pdf.2023.
3. Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Respirol Carlton Vic. 2017;22(3):575-601. doi: 10.1111/resp.13012.
4. Menezes AMB, Perez-Padilla R, Jardim JRB, et al. Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study. Lancet Lond Engl. 2005;366(9500):1875-1881. doi: 10.1016/S0140-6736(05)67632-5.
5. Seemungal TA, Donaldson GC, et al. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157(5 Pt 1):1418-1422. doi: 10.1164/ajrccm.157.5.9709032.
6. Bone RC, Balk RA, Cerra FB, et al. Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis. CHEST. 1992;101(6):1644-1655. doi: 10.1378/chest.101.6.1644.
7. Zhou W, Tan J. The expression and the clinical significance of eosinophils, PCT and CRP in patients with acute exacerbation of chronic obstructive pulmonary disease complicated with pulmonary infection. Am J Transl Res. 2021;13(4):3451-3458.
8. Li Y, Xie L, et al. Values of procalcitonin and C-reactive proteins in the diagnosis and treatment of chronic obstructive pulmonary disease having concomitant bacterial infection. Pak J Med Sci. 2017;33(3):566-569. doi: 10.12669/pjms.333.12554.
9. Anthonisen NR, Manfreda J, et al. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 1987;106(2):196-204. doi: 10.7326/0003-4819-106-2-196.
10. Nseir S, Cavestri B, Di Pompeo C, et al. Factors predicting bacterial involvement in severe acute exacerbations of chronic obstructive pulmonary disease. Respir Int Rev Thorac Dis. 2008;76(3):253-260. doi: 10.1159/000139611.
11. Lacoma A, Prat C, Andreo F, et al. Value of procalcitonin, C-reactive protein, and neopterin in exacerbations of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2011;6:157-169. doi: 10.2147/COPD.S16070.
12. Huỳnh Đình Nghĩa, Trương Dương Phi và cs. Nghiên cứu nồng độ Procalcitonin huyết thanh ở bệnh nhân nam đợt cấp bệnh phổi tắc nghẽn mạn tính có hút thuốc lá. Tạp chí Y Dược học Cần Thơ. 2019;(22-25):7.
13. Grolimund E, Kutz A, Marlowe RJ, et al. Long-term Prognosis in COPD Exacerbation: Role of Biomarkers, Clinical Variables and Exacerbation Type. COPD J Chronic Obstr Pulm Dis. 2015;12(3):300-310. doi: 10.3109/15412555.2014.949002.
14. Zou Y, Zhu Z, Zhang Y. Significance of serum procalcitonin combined with C-reactive protein in diagnosis of acute exacerbation of chronic obstructive pulmonary disease and guidance of antibiotics therapy. Int J Clin Exp Med. 2018;11(10):11070-11078.
15. Titova E, Christensen A, et al. Comparison of procalcitonin, C-reactive protein, white blood cell count and clinical status in diagnosing pneumonia in patients hospitalized with acute exacerbations of COPD: A prospective observational study. Chron Respir Dis. 2018;16:1479972318769762. doi: 10.1177/1479972318769762.
16. Black S, Kushner I, Samols D. C-reactive protein. J Biol Chem. 2004;279(47):48487-90. doi: 10.1074/jbc.R400025200.
17. Thomsen M, Dahl M, et al. Inflammatory biomarkers and comorbidities in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;186(10):982-988. doi: 10.1164/rccm.201206-1113OC.
18. Cleland DA, Eranki AP. Procalcitonin. In: StatPearls. StatPearls Publishing; 2022. Accessed February 22, 2023. http://www.ncbi.nlm.nih.gov/books/NBK539794.
19. KH Mohamed, et al. Procalcitonin as a diagnostic marker in acute exacerbation of COPD. Egyptian Journal of Chest Diseases and Tuberculosis. 2012;61(4):301-305. doi: 10.1016/j.ejcdt.2012.08.011.