The study on the relationship between the AGT gene M235T polymorphism and diabetic kidney disease
Main Article Content
Abstract
This study was conducted to assess the association of the Angiotensinogen (AGT) gene polymorphisms M235Tin diabetic kidney disease (DKD). The study was performed on 237 patients diagnosed with type 2 diabetes who agreed to perform ACR and RFLP-PCR tests from July 2015 to August 2018. The study group consisted of 117 patients with DKD, while the control group included 120 patients who are without DKD but have had type 2 diabetes for more than 10 years. The mean age of the participants was 68.3 years of age ± 8.2 years. Among 117 DKD patients, 50 (42.7%) were male and 67 (57.3%) were female. For M235T polymorphism of DKD, the frequencies of CC and (CT, TT) genotypes were 88% (n = 103) and 12% (n = 14); mean eGFR = 51.5 ± 20.6 ml/minute/1.73 m². Compared to the control group, risks of diabetic kidney disease were lower for T genotypes (CT, TT) with CC (OR: 0.7, 95% CI: 0.34 - 1.34) and CC (OR: 0.7, 95% CI: 0.32 - 1.42). In conclusion, AGT M235Tpolymorphisms are not associated with DKD in our subset of type 2 diabetes patients. Our results contribute to the better understanding of the genetic background of diabetic kidney disease.
Article Details
Keywords
AGT, M235T, Diabetic Kidney Disease, type 2 diabetes
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