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Published: 2023-04-27
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DOI: https://doi.org/10.52852/tcncyh.v165i4.1525
Issue
Vol. 165 No. 4 (2023)
Section
Các bài báo
How to Cite
Nghĩa, T. T., Tiên, N. T., Đồng, N. K., Quốc, N. H., Mai, N. T. T., Thạch, N. Đình, Thu, M. X., Khánh, T. V., & Việt, N. H. (2023). 16. Epstein-barr virus association Hexokinase 2 expression in Natural killer/t-cell lymphoma . Journal of Medical Research, 165(4), 129-136. https://doi.org/10.52852/tcncyh.v165i4.1525

16. Epstein-barr virus association Hexokinase 2 expression in Natural killer/t-cell lymphoma

Tran Tin Nghia, Nguyen Thuy Tien, Nguyen Kim Dong, Nguyen Huu Quoc, Nguyen Thi Thanh Mai, Nguyen Dinh Thach, Mai Xuan Thu, Tran Van Khanh, Nguyen Hoang Viet

Main Article Content

Abstract

Natural Killer/T cell lymphoma (NK/TL) is an aggressive type of cancer originated from the transformation of natural killer cells and T cells and is more typical in Asia. The common risk factor is Epstein-Barr virus (EBV), a member of the herpes virus family. Hexokinase 2 enzyme (HK2) expression has long been found to play a certain role in glycolysis and tumor proliferation in several cancers. Our study was conducted on 22 patients diagnosed with NK/TL to investigate the relationship between HK2 and EBV in cancer progression. HK2 expression was measured using the immunohistochemistry (IHC) technique; EBV status was determined using Realtime PCR. Our data showed 16 out of 22 research subjects (72.7%) were positive with HK2 expression. Our results showed a significant differencein EBV copy numbers in tumors between tumors not expressing HK2 and tumors expressing HK2 (p = 0.02). This can be a significant finding and suggests further research is required to understand the relationship and pathological mechanism of EBV and HK2 on NK/TL.

Article Details

Keywords

Hexokinase 2, Epstein-Barr virus, Natural Killer/T-cell Lymphoma

References

1. Park S, Ko YH. Peripheral T cell lymphoma in Asia. Int J Hematol. 2014; 99(3): 227-239. doi:10.1007/s12185-014-1520-3.
2. Young LS, Murray PG. Epstein-Barr virus and oncogenesis: from latent genes to tumours. Oncogene. 2003; 22(33): 5108-5121. doi:10.1038/sj.onc.1206556.
3. Shannon-Lowe C, Rickinson AB, Bell AI. Epstein–Barr virus-associated lymphomas. Philos Trans R Soc B Biol Sci. 2017; 372(1732): 20160271. doi:10.1098/rstb.2016.0271.
4. Wang H, Fu BB, Gale RP, Liang Y. NK-/T-cell lymphomas. Leukemia. 2021; 35(9): 2460-2468. doi:10.1038/s41375-021-01313-2.
5. Wang W, Nong L, Liang L, et al. Extranodal NK/T-cell lymphoma, nasal type without evidence of EBV infection. Oncol Lett. 2020; 20(3): 2665-2676. doi:10.3892/ol.2020.11842.
6. Mathupala SP, Ko YH, Pedersen PL. Hexokinase II: cancer’s double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene. 2006; 25(34): 4777-4786. doi:10.1038/sj.onc.1209603.
7. Roberts DJ, Miyamoto S. Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy. Cell Death Differ. 2015; 22(2): 248-257. doi:10.1038/cdd.2014.173.
8. Bhalla K, Jaber S, Nahid M N, et al. Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL. Sci Rep. 2018; 8(1): 744. doi:10.1038/s41598-018-19182-8.
9. Piccaluga PP, Weber A, Ambrosio MR, Ahmed Y, Leoncini L. Epstein–Barr Virus-Induced Metabolic Rearrangements in Human B-Cell Lymphomas. Front Microbiol. 2018; 9:1233. doi:10.3389/fmicb.2018.01233.
10. Young LS, Dawson CW, Eliopoulos AG. The expression and function of Epstein-Barr virus encoded latent genes. Mol Pathol. 2000; 53(5): 238-247.
11. Dawson CW, Port RJ, Young LS. The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC). Semin Cancer Biol. 2012; 22(2): 144-153. doi:10.1016/j.semcancer.2012.01.004.
12. Xiao L, Hu ZY, Dong X, et al. Targeting Epstein-Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy. Oncogene. 2014; 33(37): 4568-4578. doi:10.1038/onc.2014.32.
13. Fei Q, Tian XK, Wu J, et al. Prognostic significance of Epstein–Barr virus DNA in NK/T-cell lymphoma: a meta-analysis. OncoTargets Ther. 2018; 11:997-1004. doi:10.2147/OTT.S153942.
14. Lee J, Suh C, Huh J, et al. Effect of positive bone marrow EBV in situ hybridization in staging and survival of localized extranodal natural killer/T-cell lymphoma, nasal-type. Clin Cancer Res Off J Am Assoc Cancer Res. 2007; 13(11): 3250-3254. doi:10.1158/1078-0432.CCR-06-2373.
15. Liu C, Wang X, Zhang Y. The Roles of HK2 on Tumorigenesis of Cervical Cancer. Technol Cancer Res Treat. 2019; 18:1533033819871306. doi:10.1177/1533033819871306.
16. Wang H, Wang L, Zhang Y, Wang J, Deng Y, Lin D. Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth. Cancer Cell Int. 2016; 16(1): 9. doi:10.1186/s12935-016-0280-y.