3. Giá trị của một số chỉ số bạch cầu hạt mở rộng trong chẩn đoán nhiễm khuẩn huyết ở trẻ em

Abstract

Sepsis is one of the primary causes of children mortality. Early diagnosis of sepsis decreases mortality, and hospital stay duration, and improves prognosis. This study aimed to determine the diagnostic value of extended granulocyte indicators in children with sepsis. From February 2022 to February 2023, a cross-sectional, retrospective descriptive study was conducted on three patient groups, including 120 patients with sepsis, 60 patients with local infection, and 120 healthy children. White blood cells (WBC), immature granulocytes (IG#, IG%), and novel neutrophil indices (NE-SFL, NE-SSC, NE-WY) were measured and compared in 3 groups. The results showed that IG# and IG% indicators were statistically significant differences between the sepsis and other groups. Using the area under the ROC curve, IG#, IG% was better than WBC, neutrophil percentage (NEU%) in the differential diagnosis of sepsis and local infection of 0.77 and 0.76 respectively. The IG# indicator has sensitivity (Se) = 71.2% and Specificity (Sp) = 73.3% at the optimal cutoff threshold of 0.045 G/L. The IG% indicator has Se = 72.6% and Sp = 71.0% at the optimal cut-off threshold of 0.45%. Other neutrophil indicators, such as NE-SFL, NE-SSC, and NE-WY, did not reveal statistically significant differences between patient groups. Conclusion: IG# = 0.045 G/L and IG% = 0.45% are the optimal cut-off values for IG# and IG%, respectively, in diagnosing sepsis with an AUC of 0.77 and 0.76.