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Published: 2023-06-20
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DOI: https://doi.org/10.52852/tcncyh.v167i6.1708
Issue
Vol. 167 No. 6 (2023)
Section
Các bài báo
How to Cite
Anh, P. T. V., Đức, N. H. M., Năm, N. V., Minh, P. T. T., Tiến, N. V., Hải, V. X., Dung, L. N. T., Quỳnh, N. T. N., Anh, B. T. V., Hằng, N. T. T., & Hằng, Đinh T. T. (2023). 6. Evaluation of the immunostimulatory activity of imuglucan in experimental animals. Journal of Medical Research, 167(6), 43-50. https://doi.org/10.52852/tcncyh.v167i6.1708

6. Evaluation of the immunostimulatory activity of imuglucan in experimental animals

Pham Thi Van Anh, Nguyen Hoang Minh Duc, Nguyen Van Nam, Pham Thi Thuy Minh, Nguyen Viet Tien, Vu Xuan Hai, Le Nguyen Thu Dung, Nguyen Thi Nhu Quynh, Bui Thi Van Anh , Nguyen Thi Thuy Hang, Dinh Thi Thu Hang

Main Article Content

Abstract

The purpose of this study was to evaluate the immunostimulatory activity of Imuglucan on animals immunosuppressed by cyclophosphamide (CY). Mice were divided randomly into 5 groups of ten mice per cage: control, model, positive control (levamisole), Imuglucan at the dose of 153.6 mg/kg/day, and Imuglucan at the dose of 307.2 mg/kg/day. Immunosuppression in mice was induced by CY 200 mg/kg intraperitoneally. The indexes consisted of relative organ weight, leukocyte counts, OA-induced paw edema, serum IL-2, TNF-α, and IgG level and micro-histological images of spleen and thymus. As a result, Imuglucan at the dose of 307.2 mg/kg/day posed a significant immunostimulatory influence; Imuglucan at the dose of 153.6 mg/kg/day, however, only had a tendency to ameliorate the effects of CY on immunosuppressive mice.

Article Details

Keywords

Imuglucan, immunostimulatory, immunosuppression, cyclophosphamide, mice

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