37. Neonatal immune thrombocytopenia: Literature review and two cases report
Main Article Content
Abstract
Neonatal thrombocytopenia (NTP) is a common disorder of several etiological factors, most often mild and self-limiting, and is common in premature infants or in intrauterine growth retardation. However, many cases of thrombocytopenia occur in neonates due to immune mechanisms, under the influence of antiplatelet alloantibodies or maternal antiplatelet autoantibodies transmitted through the placenta. We report two cases of neonates who were found to have thrombocytopenia, and both had positive antiplatelet antibody test. The patients were excluded from the causes of thrombocytopenia and met the diagnostic criteria for immune thrombocytopenia. In conclusion, in neonates with thrombocytopenia, it is necessary to investigate the immunological sources as well as other causes in order to confirm the diagnosis and choose the optimal treatment.
Article Details
Keywords
NTP, neonates, thrombocytopenia, immune
References
2. Castle V, Andrew M, Kelton J, et al. Frequency and mechanism of neonatal thrombocytopenia. J Pediatr. 1986; 108(5 Pt 1): 749-755. doi:10.1016/s0022-3476(86)81059-9.
3. Roberts I, Murray NA. Neonatal thrombocytopenia: causes and management. Arch Dis Child - Fetal Neonatal Ed. 2003; 88(5): F359-F364. doi:10.1136/fn.88.5.F359.
4. Raju U, Arora P. Neonatal Immune Thrombocytopenia. Med J Armed Forces India. 2004; 60(4): 333-336. doi:10.1016/S0377-1237(04)80005-4.
5. Yurdakök M. Immune thrombocytopenia in the newborn. J Pediatr Neonatal Individ Med JPNIM. 2017; 6(1): e060119-e060119. doi:10.7363/060119.
6. Batton E, Leibel SL. Immune-Mediated Neonatal Thrombocytopenia. NeoReviews. 2022; 23(7): e462-e471. doi:10.1542/neo.23-7-e462.
7. Resch E, Hinkas O, Urlesberger B, et al. Neonatal thrombocytopenia-causes and outcomes following platelet transfusions. Eur J Pediatr. 2018; 177(7): 1045-1052. doi:10.1007/s00431-018-3153-7.
8. Arabdin M, Khan A, Zia S, et al. Frequency and Severity of Thrombocytopenia in Neonatal Sepsis. Cureus. 2022; 14(2): e22665. doi:10.7759/cureus.22665.
9. Dreyfus M, Kaplan C, Verdy E, et al. Frequency of Immune Thrombocytopenia in Newborns: A Prospective Study. Blood. 1997; 89(12): 4402-4406. doi:10.1182/blood.V89.12.4402.
10. Delaflor-Weiss E, Mintz PD. The evaluation and management of platelet refractoriness and alloimmunization. Transfus Med Rev. 2000; 14(2): 180-196.
11. Costedoat-Chalumeau N, Amoura Z, Le Thi Hong D, et al. Lupus néonatal: revue de la littérature [Neonatal lupus syndrome: review of the literature]. Rev Med Interne. 2003 Oct; 24(10): 659-71. French. doi: 10.1016/s0248-8663(03)00211-x. PMID: 14550519.
12. Van der Lugt NM, van Kampen A, Walther FJ, et al. Outcome and management in neonatal thrombocytopenia due to maternal idiopathic thrombocytopenic purpura. Vox Sang. 2013; 105(3): 236-243. doi:10.1111/vox.12036.