Article Sidebar

PDF (Tiếng Việt)
Published: 2023-10-02
Abstract Views: 269
Views PDF (Tiếng Việt): 180
DOI: https://doi.org/10.52852/tcncyh.v169i8.1805
Issue
Vol. 169 No. 8 (2023)
Section
Các bài báo
How to Cite
Anh, P. T. V., Hưng, L. X., Sự, P. Q., Anh, Đặng H., Quyên, Đỗ L., Hằng, Đinh T. T., & Thanh, M. P. (2023). 31. Anti-obesity effects of Mubella product in high-fat diet plus Olanzapine-induced obese mice. Journal of Medical Research, 169(8), 260-270. https://doi.org/10.52852/tcncyh.v169i8.1805 (Original work published September 20, 2023)

31. Anti-obesity effects of Mubella product in high-fat diet plus Olanzapine-induced obese mice

Pham Thi Van Anh, Luong Xuan Hung, Pham Quoc Su, Dang Hong Anh, Do Linh Quyen, Dinh Thi Thu Hang, Mai Phuong Thanh

Main Article Content

Abstract

In an attempt to find a natural antiobesity agent, this study was designed to evaluate the antiobesity activity of a novel herbal preparation Mubella composed of refined konjac meal and mulberry leaf extract in high-fat diet plus olanzapine-induced obese mice. After eight-week oral administration of the test materials to mice, the body weight gain, abdominal fat mass, and serum lipid profile were measured. Additionally, hepatic steatosis and injury were evaluated in the present study. Our results indicated that Mubella can suppress body weight gain and lower BMI in obese mice. Significant decreases in visceral abdominal fat mass were observed in Mubella-treated groups compared with the untreated obese group. Furthermore, the oral administration of Mubella improved significantly serum lipid profile, and prevent liver injury by reducing fat accumulation decreasing transaminase activities. These findings suggest that Mubella holds great promise for a novel herbal preparation with antiobesity activities, preventing body fat accumulation and altering lipid metabolism.

Article Details

Keywords

Mubella, konjac, mulberry leaf, obesity, mice

References

1. World Health Organization. Obesity and overweight fact sheet. 2021. http://www.who.int/mediacentre/factsheets/fs311/en/. Accessed 23 May 2023.
2. Ansari S, Haboubi H, Haboubi N. Adult obesity complications: challenges and clinical impact. Ther Adv Endocrinol Metab. 2020; 11:2042018820934955. doi:10.1177/2042018820934955.
3. Ruban A, Stoenchev K, Ashrafian H, Teare J. Current treatments for obesity. Clin Med (Lond). 2019; 19(3): 205-212.
4. Behera S, Ray R. Nutritional and Potential Health Benefits of Konjac Glucomannan, a Promising Polysaccharide of Elephant Foot Yam, Amorphophallus konjac K. Koch: Review. Food Reviews International. 2016; 33. doi:10.1080/87559129.2015.1137310.
5. Chan EW, Lye PY, Wong SK. Phytochemistry, pharmacology, and clinical trials of Morus alba. Chin J Nat Med. 2016; 14(1): 17-30.
6. Shertzer HG, Kendig EL, Nasrallah HA, et al. Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole. Int J Obes (Lond). 2010; 34(6): 970-979.
7. Nasrallah H. A review of the effect of atypical antipsychotics on weight. Psychoneuroendocrinology. 2003; 28 (Suppl 1): 83-96.
8. Bhana N, Foster RH, Olney R, Plosker GL. Olanzapine: an updated review of its use in the management of schizophrenia. Drugs. 2001; 61(1): 111-161.
9. Viollet B, Guigas B, Sanz Garcia N, et al. Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond). 2012; 122: 253-270.
10. Maayan L, Vakhrusheva J, Correll CU. Effectiveness of medications used to attenuate antipsychotic-related weight gain and metabolic abnormalities: a systematic review and meta-analysis. Neuropsychopharmacology. 2010; 35: 1520-1530.
11. Ziqubu K, Mazibuko-Mbeje SE, Mthembu SXH, et al. Anti-Obesity Effects of Metformin: A Scoping Review Evaluating the Feasibility of Brown Adipose Tissue as a Therapeutic Target. Int J Mol Sci. 2023; 24(3): 2227. doi: 10.3390/ijms24032227.
12. Poobalan AS, Aucott LS, Smith WCS, et al. Long-term weight loss effects on all cause mortality in overweight/obese populations. Obes Rev. 2007; 8: 503-513.
13. Aoe S, Kudo H, Sakurai S. Effects of liquid konjac on parameters related to obesity in diet-induced obese mice. Biosci Biotechnol Biochem. 2015; 79(7): 1141-1146.
14. Keithley JK, Swanson B, Mikolaitis SL, et al. Safety and efficacy of glucomannan for weight loss in overweight and moderately obese adults. J Obes. 2013; 2013: 610908. doi:10.1155/2013/610908.
15. Yang SJ, Park NY, Lim Y. Anti-adipogenic effect of mulberry leaf ethanol extract in 3T3-L1 adipocytes. Nutr Res Pract. 2014; 8(6): 613-617.
16. Oh KS, Ryu SY, Lee S, et al. Melanin-concentrating hormone-1 receptor antagonism and anti-obesity effects of ethanolic extract from Morus alba leaves in diet-induced obese mice. J Ethnopharmacol. 2009; 122(2): 216-220.
17. Zhang MY, Huang CY, Wang X, et al. The effect of foods containing refined Konjac meal on human lipid metabolism. Biomed Environ Sci. 1990; 3(1): 99-105.
18. Arvill A, Bodin L. Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men. The American Journal of Clinical Nutrition. 1995; 61(3): 585-589.
19. Huang J, Wang Y, Ying C, Liu L, Lou Z. Effects of mulberry leaf on experimental hyperlipidemia rats induced by high-fat diet. Exp Ther Med. 2018; 16(2): 547-556.
20. Aramwit P, Petcharat K, Supasyndh O. Efficacy of mulberry leaf tablets in patients with mild dyslipidemia. Phytother Res. 2011; 25(3): 365-369.