11. Effect of hyperglycemia on Covid-19 treatment results in intensive care center for Covid-19 of Bachmai Hospital

Bui Phuong Thao, Nguyen Quang Bay, Dao Xuan Co, Pham Thi Luu

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Abstract

Hyperglycemia is prevalent in Covid-19 patients and represents a poor risk factor for prognosis. Research methods: A descriptive, longitudinal research on 1163 Sar-CoV-2 patients treated at the Bach Mai’s Intensive Care Unit in Hochiminh city. Results: The prevalence of patients with hyperglycemia at hospital admission was 63.8% (741 patients). Hyperglycemia at hospital admission increased the risk of both invasive mechanical ventilation and mortality by 1.99 times (95% CI: 1.54 - 2.51) and 2.12 times (95% CI: 1.66 - 2.71) respectively compared with non-hyperglycemia. The lowest mortality rate was 43.5%, which was seen in patients with glucose level from 3.9 to 7.8 mmol/l at hospital admission. In brief, hyperglyccemia represents as a risk factor for invasive mechanical ventilation and mortality.

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References

1. Coronavirus Disease (COVID-19) Situation Reports. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports, accessed: 29/12/2021.
2. Moghissi ES, Korytkowski MT, DiNardo M, et al. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Diabetes Care. 2009; 32(6): 1119-1131. doi:10.2337/dc09-9029.
3. Coronavirus | Istituto Superiore di Sanità. https://www.epicentro.iss.it/en/coronavirus, accessed: 29/12/2021.
4. Wu J, Huang J, Zhu G, et al. Elevation of blood glucose level predicts worse outcomes in hospitalized patients with COVID-19: a retrospective cohort study. BMJ Open Diabetes Research and Care 2020; 8: e001476. doi: 10.1136/bmjdrc-2020-001476.
5. Umpierrez GE, Isaacs SD, Bazargan N, You X, Thaler LM, Kitabchi AE. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab. 2002; 87(3): 978-982. doi:10.1210/jcem.87.3.8341.
6. Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet. 2000; 355(9206): 773-778. doi:10.1016/S0140-6736(99)08415-9.
7. Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke. 2001; 32(10): 2426-2432. doi:10.1161/hs1001.096194.
8. Bode B, Garrett V, Messler J, et al. Glycemic Characteristics and Clinical Outcomes of COVID-19 Patients Hospitalized in the United States [published correction appears in J Diabetes Sci Technol. 2020 Jun 10;:1932296820932678]. J Diabetes Sci Technol. 2020; 14(4): 813-821. doi:10.1177/1932296820924469.
9. Saand AR, Flores M, Kewan T, et al. Does inpatient hyperglycemia predict a worse outcome in COVID-19 intensive care unit patients?. J Diabetes. 2021; 13(3): 253-260. doi:10.1111/1753-0407.13137.
10. Eastin C, Eastin T. Clinical Characteristics of Coronavirus Disease 2019 in China: Guan W, Ni Z, Hu Y, et al. N Engl J Med. 2020 Feb 28 [Online ahead of print] DOI: 10.1056/NEJMoa2002032. J Emerg Med. 2020; 58(4): 711-712. doi:10.1016/j.jemermed.2020.04.004.
11. Zhang JJ, Dong X, Cao YY, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020; 75(7): 1730-1741. doi:10.1111/all.14238.