Article Sidebar

PDF (Tiếng Việt)
Published: 2023-09-20
Abstract Views: 304
Views PDF (Tiếng Việt): 233
DOI: https://doi.org/10.52852/tcncyh.v169i8.1822
Issue
Vol. 169 No. 8 (2023)
Section
Các bài báo
How to Cite
Cúc, N. T., Huy, H. Q., Hằng, T. T. T., & Hùng, H. S. (2023). 16. Result of mild ovarian stimulation by Clomiphene Citrate combined with follicle stimulating hormone in -vitro at the National Hospital of Obstetrics and Gynecology. Journal of Medical Research, 169(8), 132-138. https://doi.org/10.52852/tcncyh.v169i8.1822

16. Result of mild ovarian stimulation by Clomiphene Citrate combined with follicle stimulating hormone in -vitro at the National Hospital of Obstetrics and Gynecology

Nguyen Thi Cuc, Hoang Quoc Huy, Tran Thi Thu Hang, Ho Sy Hung

Main Article Content

Abstract

This is a retrospective study on diminished ovarian reserve patients, undergoing mild ovarian stimulation, from August 2020 to August 2022 at the National Hospital of Obstetrics and Gynecology to investigate the oocytes and embryos in 2 groups (group I: Clomiphen Citrate at 100 mg/day combined with 150UI - 225UI FSH; group II: Clomiphen Citrate at 150 mg/day combined with 150UI - 225UI FSH). Results showed that the average FSH dose in group I was 168.6 ± 28.9 UI/day; group II was 164.7 ± 22.1UI/day. The number of obtained oocytes and MII oocytes of group I (5.8 ± 4.9 and 4.7 ± 3.9) were higher than group II (5.0 ± 2.6 and 3.8 ± 2.1). Total number of embryos obtained from group I was 3.8 ± 3.1, which was higher than group II, 2.95 ± 1.6. However, the difference in the number of obtained embryos between the 2 groups was not statistically significant (p > 0.05). Thus, mild ovarian stimulation is a potential approach for patients with diminished ovarian reserve where Clomiphen Citrate at 100 mg/day or 150 mg/day gave similar results.

Article Details

Keywords

Diminished ovarian reserve, mild stimulation

References

1. Jirge PR. Poor ovarian reserve. J Hum Reprod Sci. 2016; 9(2): 63-69. DOI: 10.4103/0974-1208.183514.
2. Land JA, Yarmolinskaya MI, Dumoulin JCM, et al. High-dose human menopausal gonadotropin stimulation in poor responders does not improve in vitro fertilization outcome. Fertil Steril. 1996; 65(5): 961-5. DOI: 10.1016/ s0015-0282(16)58269-7.
3. Vũ Văn Tâm, Đỗ Diễm Hường. Nghiên cứu hiệu quả của phác đồ kích thích nhẹ buồng trứng trên bệnh nhân làm thụ tinh trong ống tại bệnh viện Phụ Sản Hải Phòng, Tạp chí Phụ Sản. 2017; 16(01), 169-172.
4. Alpha Scientists In Reproductive Medicine, ESHRE Special Interest Group Embryology. Istanbul consensus workshop on embryo as- sessment: proceedings of an expert meeting. Reprod Biomed Online. 2011; 22(6): 632-646. doi:10.1016/j.rbmo.2011.02.001
5. Trịnh Thị Ngọc Yến, Dương Tiến Tùng, Hồ Nguyệt Minh. Chất lượng noãn, phôi và kết quả có thai của phác đồ kích thích buồng trứng nhẹ so với phác đồ kích thích buồng trứng liều cao ở bệnh nhân giảm dự trữ buồng trứng. Tạp chí Nghiên cứu Y học. 2022; 159(11), 132-139.
6. Vương Thị Ngọc Lan. Giá trị các xét nghiệm AMH, FSH và AFC dự đoán đáp ứng buồng trứng thụ tinh trong ống nghiệm, Đại Học Y Dược TP Hồ Chí Minh: TP Hồ Chí Minh. 2016; doi.org/10.46755/vjog.2014.1.810.
7. Polinder S, Heijnen EM, Macklon NS, Habbema JD. Cost-effectiveness of a mild compared with a standard strategy for IVF: A randomized comparison using cumulative term live birth as the primary endpoint. Hum Reprod. 2008; 23(2): 316-23. DOI: 10.1093/humrep/dem372
8. Youssef MA, van Wely M, Mochtar M, et al. Low dosing of gonadotropins in in vitro fertilizationcycles for women with poor ovarian reserve: Systematic review and meta-analysis. Fertil Steril. 2017; 109(2): 289-301.
9. Baart, Esther B., et al. Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial. Human Reproduction. 2007; 22(4): 980-988.
10. Irani, M., et al. No effect of ovarian stimulation and oocyte yield on euploidy and live birth rates: an analysis of 12 298 trophectoderm biopsies. Human Reproduction. 2020; 35(5): 1082-1089.