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Published: 2023-09-20
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DOI: https://doi.org/10.52852/tcncyh.v169i8.1860
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Vol. 169 No. 8 (2023)
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Hậu, T. T., & Thế, Đào M. (2023). 29. The clinical, subclinical, and the efficacy of first-line chemotherapy in stage IV non-small cell lung cancer patients harboring EGFREGFR exon 20 insertions. Journal of Medical Research, 169(8), 242-250. https://doi.org/10.52852/tcncyh.v169i8.1860

29. The clinical, subclinical, and the efficacy of first-line chemotherapy in stage IV non-small cell lung cancer patients harboring EGFREGFR exon 20 insertions

Tran Thi Hau, Dao Minh The

Main Article Content

Abstract

Epidermal growth factor receptor mutation exon 20 insertion ranks third in all non-small cell lung cancer harboring EGFR mutation. The disease has a poor prognosis and is often resistant to tyrosine kinase inhibitors drugs, so the standard treatment is still platinum-based chemotherapy. This is a cross-sectional descriptive study of 31 patients with stage IV non-small cell lung cancer harboring EGFR exon 20 insertions treated with first-line platinum-based chemotherapy from January 2019 to June 2023 at K Hospital; we report clinical and subclinical features and the efficacy of first-line chemotherapy for the aforementioned patients. The study showed the mean age was 59.14, predominantly males; the male/female ratio was 2.1/1. Most patients were former smokers (67.7%) and their performance status (PS) 1 was 77.4%. Prolonged cough was the most common reason for hospitalization, followed by chest pain. Hemoptysis was the lowest rate. T4 was the highest rate at 48.4%. Lymph nodes metastatic N2-3 was 71%. Bone was the most propensity site for metastatic, followed by contralateral lung, pleural, brain, and adrenal gland metastasis. Adenocarcinoma was the predominant histology at 93.5%. Pemetrexed-carboplatin was the most commonly used, accounting for 51.6%, and the overall response to chemotherapy was 25.8%. Median progression-free survival was five months. The study revealed that stage IV non-small cell lung cancer patients harboring EGFR exon 20 insertions was commonly seen in young males with bone metastasis; the disease has a poor prognosis with the overall response rate and progression-free survival were relatively low. 

Article Details

Keywords

Non-small cell lung cancer, EGFR, exon 20 insertion

References

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