6. Đặc điểm lâm sàng, cận lâm sàng và kết quả điều trị nhiễm khuẩn huyết do Staphylococcus aureus ở trẻ sơ sinh

Abstract

The study was conducted to describe the clinical, subclinical and therapeutic outcomes of Staphylococcus aureus (S.aureus) sepsis in newborns at the Neonatal Center, National Children's Hospital from January 2022 to June 2023. Among the 38 neonatans, hospitalizations were dominated by poor feeding (78.9%), fever (76.3%), and lethargy (34.2%). Respiratory manifestations accounted for 71.1%, the majority being tachypnea (44.7%) and moist rales (44.7%). Lbaoratory results shows leukocyte ratio ≥ 20 G/L (39.5%), < 5 G/L (10.6%), granulocytopenia < 1.5 G/L (7.8%), thrombocytopenia < 150 G/L (18.8%), CRP ≥ 15 mg/L (78.9%). X-ray lesions are diverse as faint nodules (73.6%), consolidation (39.5%), pleural effusion (21.1%), pneumothorax (15.8%), air balloons (7.8%). There were 25/38 (65.8%) solitary positive blood culture patients, 13/38 (34.2%) combined with another site. S. aureus is also sensitive to many antibiotics such as vancomycin (100%), linezolid (100%), ciprofloxacin (92.1%), and levofloxacin (92.1%). The average duration of treatment was 21.2 ± 11.8 days, the mortality rate was 13.2%. Clinical and subclinical manifestations of S. aureus in neonates are diverse, often in the respiratory organs. Despite being sensitive to many antibiotics, many cases do not respond to treatment, leading to high mortality. As such, it is important  to improve early diagnosis and timely treatment of the disease.