30. Primary mucinous skin cancer: A case report and review of the literature
Main Article Content
Abstract
Primary mucinous carcinoma of the skin (PMCS) is an extremely uncommon skin cancer originating from sweat glands. We present a case of a male patient diagnosed with PMCS who was initially misdiagnosed with benign sebaceous cysts. A 62-year-old male patient presented to a private clinic with a chief complaint of a slowly progressing nodule located under his lower lip for the past two years; The nodule was locally excised . The histopathology analysis yielded a diagnosis of mucinous carcinoma with a positive circumferential margin. Reexcison was performed, and the final histopathology result was a small nest of mucinous carcinoma with a negative surgical margin. He underwent thorough investigation, including gastroduodenoscopy, colonoscopy, and computerized tomography (CT) scans of the chest, abdomen, and pelvis, and found no signs of primary tumor. He was discharged from our hospital and educated to follow up closely for local recurrence. This paper illustrates the rarity of this disease, its vague presentation, and a brief review of diagnosis and treatment.
Article Details
Keywords
Primary mucinous carcinoma, skin.
References
2. Breiting L, Dahlstrøm K, Christensen L, Winther JF, Breiting V. Primary Mucinous Carcinoma of the Skin. Am J Dermatopathol. 2007; 29(6): 595. doi:10.1097/DAD.0b013e318158d878.
3. Behbahani S, Pinto JO, Wassef D, Povolotskiy R, Paskhover B. Analysis of Head and Neck Primary Cutaneous Mucinous Carcinoma: An Indolent Tumor of the Eccrine Sweat Glands. J Craniofac Surg. 2021; 32(3): e244-e247. doi:10.1097/SCS.0000000000006968.
4. Lennox B, Pearse AGE, Richards HGH. Mucin-secreting tumours of the skin with special reference to the so-called mixed-salivary tumour of the skin and its relation to hidradenoma. J Pathol Bacteriol. 1952; 64(4): 865-880. doi:10.1002/path.1700640418.
5. Mendoza S, Helwig EB. Mucinous (adenocystic) carcinoma of the skin. Arch Dermatol. 1971; 103(1): 68-78.
6. Breiting L, Christensen L, Dahlstrøm K, Breiting V, Winther JF. Primary mucinous carcinoma of the skin: a population-based study. Int J Dermatol. 2008; 47(3): 242-245. doi:10.1111/j.1365-4632.2008.03558.x.
7. Primary cutaneous mucinous carcinoma: A rare entity - PMC. Accessed July 26, 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481811/.
8. Maerki J, Ahmed S, Lee E. Primary Mucinous Carcinoma of the Skin. Eplasty. 2013;13:ic47.
9. Tillit SM, Iyer SSR, Grieser EJ, LiVecchi JT. Treatment of Recurrent Primary Cutaneous Mucinous Carcinoma of the Eyelid with Modified Wide Local Excision. Case Rep Ophthalmol Med. 2020; 2020:e6668640. doi:10.1155/2020/6668640.
10. Jhunjhunwala AK, Gharti Magar D, Upreti D, et al. Mucinous Carcinoma of the Skin: A Case Report. JNMA J Nepal Med Assoc. 2022; 60(248): 402-405. doi:10.31729/jnma.7415.
11. Ohnishi T, Takizawa H, Watanabe S. Immunohistochemical analysis of cytokeratin and human milk fat globulin expression in mucinous carcinoma of the skin. J Cutan Pathol. 2002; 29(1): 38-43. doi:10.1046/j.0303-6987.2001.00039.x.
12. Qureshi HS, Salama ME, Chitale D, et al. Primary cutaneous mucinous carcinoma: presence of myoepithelial cells as a clue to the cutaneous origin. Am J Dermatopathol. 2004; 26(5): 353-358. doi:10.1097/00000372-200410000-00001.
13. Kelly A, Anand R, Natkunarajah J, Samarasinghe V, Craythorne E. Mohs micrographic surgery for the treatment of primary cutaneous mucinous carcinoma. Clin Exp Dermatol. 2023; 48(7): 778-780. doi:10.1093/ced/llad057.