33. Pregnancy results of frozen embryo transfer using natural and artificial cycles in uterine endometrial preparation protocols
Main Article Content
Abstract
Preparing the uterine endometrial for embryo transfer using artificial cycles and natural cycles are the two most popular protocols. This is a prospective study conducted on 85 patients undergoing frozen embryo transfer from September 2022 to August 2023 at the ART Central, National Hospital of Obstetrics and Gynecology to compare pregnancy rates between artificial and natural cycle protocols. The results showed there was no statistically significant difference in age, body mass index (BMI), cause of infertility, duration of infertility, type of infertility in the two groups. The uterine endometrial thickness on the day of progesterone in the artificial cycle group was statistically significantly thicker than inthe natural cycle (10.07 ± 2.53mm compared to 8.86 ± 2.31mm, p = 0.002). However, pregnancy rate (73.68% vs 63.33%, p = 0.71), clinical pregnancy (63.16% vs 56.67%, p = 0.84), biochemical pregnancy (10.53% vs. 6.67%, p = 0.69) was not statistically different between two groups. uterine endometrial preparation using natural cycle or artificial cycles for frozen embryo transfer gives equivalent pregnancy results. The cycle cancel rate in the natural cycles tends to be higher than the artificial cycle while the natural cycle requires less medication.
Article Details
Keywords
Natural cycle, artificial cycle, endometrial preparation, frozen embryo transfer
References
2. El-Toukhy T, Taylor A, Khalaf Y, et al. Pituitary suppression in ultrasound-monitored frozen embryo replacement cycles. A randomised study. Hum Reprod Oxf Engl. 2004; 19(4): 874-879. doi:10.1093/HUMREP/DEH183.
3. Ghobara T, Gelbaya TA, Ayeleke RO. Cycle regimens for frozen-thawed embryo transfer. Cochrane Database Syst Rev. 2017; 2017(7). doi:10.1002/14651858.CD003414.PUB3.
4. Liu X, Shi W, Shi J. Natural cycle frozen-thawed embryo transfer in young women with regular menstrual cycles increases the live-birth rates compared with hormone replacement treatment: a retrospective cohort study. Fertil Steril. 2020; 113(4): 811-817. doi:10.1016/j.fertnstert.2019.11.023.
5. Moreno-Sepulveda J, Espinós JJ, Checa MA. Lower risk of adverse perinatal outcomes in natural versus artificial frozen–thawed embryo transfer cycles: a systematic review and meta-analysis. Reprod Biomed Online. 2021; 42(6): 1131-1145. doi:10.1016/j.rbmo.2021.03.002.
6. Zhang Y, Fu X, Gao S, et al. Preparation of the endometrium for frozen embryo transfer: an update on clinical practices. Reprod Biol Endocrinol RBE. 2023; 21(1). doi:10.1186/S12958-023-01106-5.
7. Peeraer K, Couck I, Debrock S, et al. Frozen–thawed embryo transfer in a natural or mildly hormonally stimulated cycle in women with regular ovulatory cycles: a RCT. Hum Reprod. 2015; 30(11): 2552-2562. doi:10.1093/HUMREP/DEV224.
8. Peeraer K, Couck I, Debrock S, et al. Frozen–thawed embryo transfer in a natural or mildly hormonally stimulated cycle in women with regular ovulatory cycles: a RCT. Hum Reprod. 2015; 30(11): 2552-2562. doi:10.1093/HUMREP/DEV224.
9. Kim YJ, Choi YS, Lee WD, et al. Does a vitrified blastocyst stage embryo transfer program need hormonal priming for endometrial preparation? J Obstet Gynaecol Res. 2010; 36(4): 783-788. doi:10.1111/J.1447-0756.2010.01243.X.
10. Cardenas Armas DF, Peñarrubia J, Goday A, et al. Frozen-thawed blastocyst transfer in natural cycle increase implantation rates compared artificial cycle. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol. 2019; 35(10): 873-877. doi:10.1080/09513590.2019.1600668.