1. Đặc điểm lâm sàng, cận lâm sàng của phản ứng sau tiêm chủng ở trẻ em dưới 5 tuổi được điều trị tại Bệnh viện Nhi Trung ương năm 2019 - 2021

Abstract

Our research was conducted at the National Children's Hospital from January 2019 to December 2021, employing a cross-sectional descriptive research methodology involving 103 children under 5 years of age who had undergone vaccination. The study aimed to explore both clinical and subclinical features of vaccination reactions in children. The key findings are as follows: The most prevalent reaction, observed in 47.6% of the children, was a high fever (> 38.5°C). Secondly, crying was reported in 10.6% of cases, difficulty breathing in 8.7%, and pallor in 7.7%. Additionally, 6.8% of the children experienced symptoms such as feeding difficulties, while 5% encountered other reactions, including hives, pain at the injection site, seizures, vomiting, diarrhea, and edema. Additional signs, such as petechiae, cold skin, fatigue, and an elevated heart rate, were also documented. Vaccine type 5.1 demonstrated the highest incidence of post-vaccination reactions. 55.3% exhibited elevated C-reactive protein (CRP) levels, while the remaining 44.7% maintained normal CRP levels, with an average value of approximately 11.7 mg/L. The majority of reactions occurred in children under 6 months of age, predominantly after the administration of vaccine 5.1. In most cases, symptoms manifested early, with fever and feeding difficulties being the most common, and most children exhibited normal subclinical outcomes.