19. Correlation between urine protein/creatinin ratio and 24-hour proteinuria in Lupus nephritis
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Abstract
This study aimed to assess the correlation between the random urine protein/creatinine ratio (UPCR) and 24-hour proteinuria (24h-UP) in patients newly diagnosed with lupus nephritis (LN). This cross-sectional descriptive study included 51 patients who were diagnosed with LN according to SLICC 2012 criteria, and treated at the Center for Allergy - Clinical Immunology, Bach Mai Hospital from October 2022 to August 2023. Both random and 24-hour urine samples were collected from each participant. The average age at LN diagnosis was 36 ± 14. Most were female (~ 90%). The mean duration from systemic lupus erythematosus (SLE) to LN onset was 2.07 ± 3.96 years. The 24h-UP at the level nephrotic syndrome was 41.2%. The mean of UPCR was 399.74 ± 443.89 mg/mmol. UPCR was strongly correlated with 24h-UP, with r = 0.833, p = 0.000. The equation of linear correlation between UPCR and 24h-UP was determined as: 24h-UP = 0.0081 x UPCR + 0.703. This study showed a strong correlation between urinary protein/creatinine ratio in random urine samples and 24-hour proteinuria in patients with newly diagnosed with LN, suggesting the potential of UPCR as a screening measure in clinical practice.
Article Details
Keywords
Systemic lupus erythematosus (SLE), lupus nephritis (LN), urine protein creatinin ratio (UPCR), 24-hour proteinuria (24h-UP)
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