17. Outcomes of hepatectomy for hepatolithiasis: A retrospective analysis of 45 patients at Bach Mai Hospital

Tran Que Son, Hoang Xuan Minh, Tran Hieu Hoc

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Abstract

Treatment of hepatolithiasis requires multidisciplinary coordination, but there is still a high rate of incomplete clearance of stones. Alternatively, liver resection has been proposed as a definitive treatment for segmental hepatolithiasis because it treats not only the stones, but also strictures and atrophic and inflammatory changes. The objective of the study is to describe the clinical characteristics and outcomes of hepatectomy to treat hepatolithiasis. We performed a retrospective study of patients undergoing liver resection due to stones at Bach Mai Hospital by a single surgeon from January 2016 to October 2023. Preoperative, intraoperative, and postoperative variables were evaluated. Results: A total of 45 patients underwent hepatectomy for hepatolithiasis. The mean ± standard deviation patient age was 52.3 ± 10.3 years (range: 31 - 78 years); male/female ratio was 2.4. The main presenting symptom was abdominal pain (88.9 %). Hepatic involvement was noted in the left lateral segment in 71.1% and bilaterally in 28.9% of subjects. The most frequent procedure was left lateral sectionectomy and left hepatectomy which was conducted in 93.3% and 6.7% of patients, respectively. The mean operative time was 130.2 ± 35.5 min (range: 80 - 240 min). The mean hospital stay was 8.8 ± 2.9 days (range: 6 - 16 days). Complete clearance of the biliary system was achieved in 43 (95.5%) patients. Postoperative morbidity was 17.8% and there were no postoperative deaths. Conclusion: anatomic hepatectomy is an effective method in localized hepatolithiasis patients with low morbidity and no mortality. Long-term follow-up is needed to determine the risk of complications and recurrence rate.

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References

1. Nguyễn Cao Cương, Phan Hiệp Lợi, Lê Văn Cường, và cs. Cắt gan điều trị sỏi trong gan. Tạp chí Y học TP Hồ Chí Minh. 2004;8(1):268-273.
2. Dương Văn Hải, Văn Tần. Chỉ định và kết quả phẫu thuật điều trị sỏi trong gan. Tạp chí Y học TP Hồ Chí Minh. 2006;10:360-367.
3. Feng X, Zheng S, Xia F, et al. Classification and management of hepatolithiasis: A high-volume, single-center’s experience. Intractable Rare Dis Res. 2012;1(4):151-156.
4. Li SQ, Liang LJ, Peng BG, et al. Outcomes of liver resection for intrahepatic stones: a comparative study of unilateral versus bilateral disease. Ann Surg. 2012;255(5):946-953.
5. Lin CC, Lin PY, Ko CJ, et al. Hepatic resection for bilateral hepatolithiasis: a 20-year experience. ANZ J Surg. 2013;83(12):978-984.
6. Wen XD, Wang T, Huang Z, et al. Step-by-step strategy in the management of residual hepatolithiasis using post-operative cholangioscopy. Therap Adv Gastroenterol. 2017;10(11):853-864.
7. Torres OJM, Linhares MM, Ramos EJB, et al. Liver Resection for Non-Oriental Hepatolithiasis. Arq Bras Cir Dig. 2019;32(4):e1463.
8. Đoàn Văn Trân, Nguyễn Thanh Sáng, Trịnh Du Dương, và cs. Vai trò của nội soi đường mật trong cắt gan điều trị sỏi. Tạp chí Y học Lâm sàng - Bệnh viện TW Huế. 2019;53:84 - 91.
9. Đỗ Tuấn Anh. Đánh giá kết quả ứng dụng kỹ thuật cắt gan theo phương pháp Tôn Thất Tùng trong điều trị bệnh sỏi trong gan. Luận án Tiến sĩ Y học. Học viện Quân Y. 2008.
10. Lorio E, Patel P, Rosenkranz L, et al. Management of Hepatolithiasis: Review of the Literature. Curr Gastroenterol Rep. 2020;22(6):30.
11. Li H, Zheng J, Cai JY, et al. Laparoscopic VS open hepatectomy for hepatolithiasis: An updated systematic review and meta-analysis. World J Gastroenterol. 2017;23(43):7791-7806.
12. Tabrizian P, Jibara G, Shrager B, et al. Hepatic resection for primary hepatolithiasis: a single-center Western experience. J Am Coll Surg. 2012;215(5):622-626.
13. Kim HJ, Kim JS, Joo MK, et al. Hepatolithiasis and intrahepatic cholangiocarcinoma: A review. World J Gastroenterol. 2015;21(48):13418-13431.
14. Văn Tần. Cắt gan, xẻ gan hay phối hợp để lấy sỏi trong gan: Đặc điểm, chỉ định và kết quả. Tạp chí Y học TP Hồ Chí Minh. 2002;6(2):252 -262.
15. Xia H, Meng X, Xin X, et al. Resection of extrahepatic bile ducts with partial hepatectomy for treating intra- and extrahepatic hepatolithiasis. BMC Surg. 2021;21(1):420.
16. Uenishi T, Hamba H, Takemura S, et al. Outcomes of hepatic resection for hepatolithiasis. Am J Surg. 2009;198(2):199-202.
17. Jarufe N, Figueroa E, Munoz C, et al. Anatomic hepatectomy as a definitive treatment for hepatolithiasis: a cohort study. HPB (Oxford). 2012;14(9):604-610.
18. Shah OJ, Robbani I, Shah P, et al. Left-sided hepatic resection for hepatolithiasis: a longitudinal study of 110 patients. HPB (Oxford). 2012;14(11):764-771.
19. Kim HJ, Kang TU, Swan H, et al. Incidence and Prognosis of Subsequent Cholangiocarcinoma in Patients with Hepatic Resection for Bile Duct Stones. Dig Dis Sci. 2018;63(12):3465-3473.
20. Kim HJ, Kim JS, Suh SJ, et al. Cholangiocarcinoma Risk as Long-term Outcome After Hepatic Resection in the Hepatolithiasis Patients. World J Surg. 2015;39(6):1537-1542.