5. Nguy cơ tái phát bệnh võng mạc trẻ sinh non sau điều trị tiêm Aflibercept

Abstract

This study was conducted to evaluate risk factors of reactivation of retinopathy of prematurity after aflibercept intravitreal injection treatment. The reactivation rate after treatment was 37/244 eyes (15.16%). Factors affecting the reactivation of retinopathy of prematurity after aflibercept intravitreal injection treatment include: gestational age, postmenstrual age at the time of injection, weight at birth, weight at the time of injection, height at the time of injection, newborn head circumference, head circumference at the time of injection, newborn chest circumference, history of blood transfusion, body mass index at the time of injection, and history of nuchal cord. The reactivation rate of group with birth weight under 900g was 28.38%, followed by the group with average birth weight (12.20%) and the group with birth weight over 1200g (6.82%). The time of reactivation in the three groups was 9.82 ± 5.76 weeks, 10.20 ± 3.27 weeks and 12.33 ± 9.24 weeks, respectively. The lower the birth weight, the higher and earlier the disease reactivation rate.