Article Sidebar

PDF (Tiếng Việt)
Published: 2024-03-29
Abstract Views: 153
Views PDF (Tiếng Việt): 149
DOI: https://doi.org/10.52852/tcncyh.v175i2.2220
Issue
Vol. 175 No. 2 (2024)
Section
Các bài báo
How to Cite
Anh, . H. T. K., Thúy, N. T., Khánh, T. V., Liên, N. Đức, Linh, N. V., Phương, L. T., Tuấn, P. L. A., Việt, N. H., Duy, N. V., & Hùng, K. Đình. (2024). 10. Evaluation of miRNA-20a expression level in glioma patients. Journal of Medical Research, 175(2), 79-84. https://doi.org/10.52852/tcncyh.v175i2.2220

10. Evaluation of miRNA-20a expression level in glioma patients

Hua Thi Kim Anh, Nguyen Thu Thuy, Tran Van Khanh, Nguyen Duc Lien, Nguyen Van Linh, Le Thi Phuong, Pham Le Anh Tuan, Nguyen Hoang Viet, Nguyen Van Duy, Kieu Dinh Hung

Main Article Content

Abstract

Glioma is a primary brain tumor driven from abnormal growth of poorly differentiated or anaplastic glial cells. Many studies have shown that upregulated expression of miR-20a is related to disease progression, poor survival and high mortality of glioma. This study aimed to evaluate miR-20a expression level in the peripheral blood of glioma patients after surgery. The expression level of miR-20a of 62 post-operative gliomas and 62 healthy controls was quantified by Realtime-PCR technique. The results showed that miR-20a expression level was significantly lower in the glioma group (0.264 ± 0.342) than that in control group (0.659 ± 0.841) (p < 0.001). This data suggests a relation between the decrease of miR-20 expression level and glioma.

Article Details

Keywords

Gliomas, miR-20a, expression level

References

1. Parsons DW, Jones S, Zhang X, et al. An Integrated Genomic Analysis of Human Glioblastoma Multiforme. Science. 2008; 321(5897): 1807. doi:10.1126/science.1164382.
2. Aum DJ, Kim DH, Beaumont TL, Leuthardt EC, Dunn GP, Kim AH. Molecular and cellular heterogeneity: the hallmark of glioblastoma. Neurosurg Focus. 2014; 37(6): E11. doi:10.3171/2014.9.FOCUS14521.
3. MicroRNAs: Genomics, Biogenesis, Mechanism, and Function - ScienceDirect. Accessed January 4, 2024. https://www.sciencedirect.com/science/article/pii/S0092867404000455.
4. Wang Z, Wang B, Shi Y, et al. Oncogenic miR-20a and miR-106a enhance the invasiveness of human glioma stem cells by directly targeting TIMP-2. Oncogene. 2015; 34(11): 1407-1419. doi:10.1038/onc.2014.75.
5. Liao C, Chen W, Wang J. MicroRNA-20a Regulates Glioma Cell Proliferation, Invasion, and Apoptosis by Targeting CUGBP Elav-Like Family Member 2. World Neurosurgery. 2019; 121: e519-e527. doi:10.1016/j.wneu.2018.09.155.
6. Zhou D, Wan Y, Xie D, et al. DNMT1 mediates chemosensitivity by reducing methylation of miRNA-20a promoter in glioma cells. Exp Mol Med. 2015; 47(9): e182-e182. doi:10.1038/emm.2015.57.
7. Zhi F, Shao N, Wang R, et al. Identification of 9 serum microRNAs as potential noninvasive biomarkers of human astrocytoma. Neuro Oncol. 2015; 17(3): 383-391. doi:10.1093/neuonc/nou169.
8. Yu Y, Zhang J, Jin Y, et al. MiR-20a-5p suppresses tumor proliferation by targeting autophagy-related gene 7 in neuroblastoma. Cancer Cell International. 2018; 18(1): 5. doi:10.1186/s12935-017-0499-2.
9. Zhao H, Shen J, Hodges TR, Song R, Fuller GN, Heimberger AB. Serum microRNA profiling in patients with glioblastoma: a survival analysis. Mol Cancer. 2017; 16: 59. doi:10.1186/s12943-017-0628-5.