Article Sidebar

PDF (Tiếng Việt)
Published: 2024-05-31
Abstract Views: 59
Views PDF (Tiếng Việt): 52
DOI: https://doi.org/10.52852/tcncyh.v177i4E14.2354
Issue
Vol. 177 No. 4E14 (2024)
Section
Các bài báo
How to Cite
Anh, P. T. V., Thuy, N. T., Hoai, N. Q., & Duong, D. T. (2024). 17. Nasal irritation of Mui Xoang Nhat Nhat spray in experimental animals. Journal of Medical Research, 177(4E14), 132-138. https://doi.org/10.52852/tcncyh.v177i4E14.2354

17. Nasal irritation of Mui Xoang Nhat Nhat spray in experimental animals

Pham Thi Van Anh, Nguyen Thi Thuy, Nguyen Quoc Hoai, Dau Thuy Duong

Main Article Content

Abstract

Mui xoang Nhat Nhat (MXNN) spray is a herbal combination of Angelica dahurica, Xanthium strumarium L., Ageratum conyzoides L, which is intended to use as the supportive treatment of stuffy nose, runny nose in some upper respiratory diseases such as rhinitis and sinusitis. This study was carried out to evaluate the nasal mucosa irritation of MXNN spray in experimental animals. Rabbits were divided into 3 groups: group 1 administered 0.9% sodium chloride, group 2A and 2B administered MXNN spray 2 puffs for each nostril, 3 times a day for 5 days. The investigational product was discontinued for 7 days for Group 2B rabbits to evaluate the recovery from the lessions. At the end of the experimental period, the rabbits were grossly and microscopically evaluated. Our results showed that MXNN spray caused slight irritation, which might cause vascular congestion in the submucosa layer and could be mostly recovered in a week in rabbits.

Article Details

Keywords

Mui Xoang Nhat Nhat, nasal spray, irritation, nasal mucosa, rabbits

References

1. Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2014; 4:177.
2. Doris kumadoh, Kwabena ofori-kwakye. Dosage forms of herbal medicinal products and their stability considerations-an overview. J Crit rev. 2017; vol 4, issue 4, 1-8.
3. Savic, Snezana & Milić, Jela. Nasal preparations: Conventional and advanced pharmaceutical dosage forms. Arhiv za Farmaciju. 2011; 61, 177-193.
4. Scherließ R. Nasal formulations for drug administration and characterization of nasal preparations in drug delivery. Ther Deliv. 2020; 11(3):183-191.
5. Cankaya H, Ozen S, Kiroğlu F, Yurttaş V.. Effects of topical chlorhexidine applied to the rabbit nasal mucosa, Auris Nasus Larynx. 2003; 30(1):65-9.
6. Min Wang, Shan Wang, Yi Zhang. Studies of Mucosal Irritation and Cellular Uptake Mechanisms of Xingnaojing Nanoemulsion, Braz. J. Pharm. 2022; 58: e20241.
7. Wang AJ, Li X, Wang H. Nasal mucosa and mucociliary toxicity study of compound tetramethylpyrazine. Pharmacol Clin Chin Materia Medica. 2016; 32(1):141-145.
8. Zhao H, Feng YL, Wang M, Wang JJ, Liu T, Yu J. The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology. Front Pharmacol. 2022; 13.
9. Li D, Wu L. Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation. Exp Ther Med. 2017; 14(1): 874-880.
10. Qianhua Peng, RuiXiang Chen. Biosynthesis of gold nanoparticles using Caffeoylxanthiazonoside, chemical isolated from Xanthium strumarium L. fruit and their anti-allergic rhinitis effect- a traditional Chinese medicine. Journal of Photochemistry and Photobiology B: Biology. 2019; Volume 192, 13-18.
11. Peng W, Ming QL, Han P, Zhang QY, Jiang YP, Zheng CJ, Han T, Qin LP. Anti-allergic rhinitis effect of caffeoylxanthiazonoside isolated from fruits of Xanthium strumarium L. in rodent animals. Phytomedicine. 2014;21(6):824-9.
12. Kamboj, Anjoo & Saluja, Ajay Kumar. Ageratum conyzoides L.: A review on its phytochemical and pharmacological profile. International Journal of Green Pharmacy. 2008; 2.10.