Characteristics of coronary artery lesions in intravenous immunoglobulin - non - responsive kawasaki disease
Main Article Content
Abstract
The study was conducted to compare characteristics and progression of coronary artery lesions (CALs) between the intravenous immunoglobulin (IVIG) -responsive and non-responsive patients in 251 patients diagnosed with Kawasaki disease in Vietnam National Children’s Hospital. This was a prospective observational study. The research results notes that: among 251 patients included in the study, 35 patients were IVIG-non-responsive (13.9%). The IVIG-non-responsive patients experienced more sites of CALs at higher rates and severity than responsive patients (p < 0.05). After 6 months, 52.3% of patients who had CALs in acute phases recovered completely. The recovery rate of the IVIG- responsive group was significantly higher than that of the non-responsive group (61.2% versus 23.8%, p < 0.05). The patients’ ability to response to IVIG and the severity of CALs in acute phases influenced the ability to recover. This relationship alludes to the poor prognoses of patients with more severe CALs. In the CALs patients, C-reactive protein (CRP) levels before IVIG ≥ 119.4 mg/L and the neutrophil count before IVIG ≥ 10.4 G/L were independent risk factors for the IVIG- non-responsiveness.
Article Details
Keywords
Kawasaki Disease, intravenous immunoglobulin, coronary artery lesions
References
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