17. Kết quả điều trị viêm tụy cấp có rối loạn đông máu ở trẻ em tại Bệnh viện Nhi Trung ương

Abstract

Acute pancreatitis is a severe inflammation of the pancreas presented with a high morbidity and mortality rate if accompanied by severe local and systemic complications. Alterations in coagulation factors have been reported during acute pancreatitis. The objective of the study is to evaluate the outcomes of AP with coagulation disorders in children at the National Children's Hospital from January 2022 to July 2023. A descriptive study was conducted in 53 children diagnosed with acute pancreatitis according to the 2012 revised Atlanta criteria. These children exhibited at least one coagulation test result outside the age-appropriate range. Among the participants, 52.8% were male and 47.2% were female, with a median age of 5.5 years old. The findings indicate that 92.5% of patients responded positively to single medical management, with 86.8% achieving complete recovery and 13.2% experiencing relapses. Among D-Dimer concentrations exceeding 5000 ng/mL group, the rates of peripancreatic fluid collection (76.7%) and free intra-abdominal fluid (83.3%) were higher compared to those with D-Dimer concentrations below 5000 ng/mL, (43.5% and 52.2%, respectively). The duration of hospitalization in a higher D-Dimer levels group was longer (12.5 days (IQR: 8 - 17 days)) than the lower one (9 days (IQR: 7.5 - 13 days)). Nevertheless, no disparity in treatment outcomes was observed between the two groups.