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Published: 2024-06-20
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DOI: https://doi.org/10.52852/tcncyh.v178i5.2398
Issue
Vol. 178 No. 5 (2024)
Section
Các bài báo
How to Cite
Trang, T. G. ., Oanh, L. H. ., Thương, P. T. ., Dương, N. T. ., Châu, H. M. ., Dương, Đậu T. ., Trang, T. Q. ., Thúy, N. T. ., Anh, P. T. V. ., & Hằng, Đinh T. T. . (2024). 30. Subchronic toxicity evaluation of Gymnema sylvestre extract in experimental animals. Journal of Medical Research, 178(5), 259-267. https://doi.org/10.52852/tcncyh.v178i5.2398

30. Subchronic toxicity evaluation of Gymnema sylvestre extract in experimental animals

Tran Gia Trang, Le Hong Oanh, Phuong Thien Thuong, Nguyen Thuy Duong, Hoang Minh Chau, Dau Thuy Duong, Tran Quynh Trang, Nguyen Thi Thuy, Pham Thi Van Anh, Dinh Thi Thu Hang

Main Article Content

Abstract

Objective: The research was conducted to evaluate the sub-chronic toxicity of Gymnema sylvestre extract through oral administration in experimental animals. The sub-chronic toxicity study was conducted by the recommendation of the WHO in Wistar rats with oral doses of 50 mg/kg/day and 250 mg/kg/day in 12 consecutive weeks. Results: oral administration of Gymnema sylvestre extract at 50 mg/kg/day and 250 mg/kg/day had no effect on general condition, body weight, hematological parameters, hepato-renal functions and histopathological structures of liver and kidney. In conclusion, Gymnema sylvestre extract did not appear to produce sub-chronic toxicity in rats.

Article Details

Keywords

Gymnema sylvestre extract, sub-chronic toxicity, Wistar rats

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