7. Clinical and microbiological characteristics of Staphylococcus aureus sepsis in children at National Children’s Hospital
Main Article Content
Abstract
Sepsis caused by Staphylococcus aureus is one of the most common and important infections in children. Panton-Valentine Leukocidin (PVL) - a toxin of Staphylococcus aureus - bring about tissue necrosis and white blood cells destruction; as such, it plays an important role in the pathogenesis thus significantly reduces the effectiveness of treatment of sepsis in children. We conducted a cross sectional study on 145 children diagnosed with sepsis caused by Staphylococcus aureus at the National Children's Hospital from September 2022 to September 2023. to describe clinical characteristics, antimicrobial resistance and determination of the prevelance of Staphylococcus aureus strains carrying the pvl gene that causes bacteremia in children. Staphylococcus aureus strains carrying the pvl gene that causes infections in children represented 85.5%, in which the proportion of MRSA strains carrying the pvl gene is higher than MSSA. We noted no difference between the clinical characteristics of infections caused by MRSA and MSSA. All Staphylococcus aureus strains causing sepsis in the study were sensitive to vancomycin.
Article Details
Keywords
Sepsis, Children, Staphylococcus aureus
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