Article Sidebar

PDF (Tiếng Việt)
Published: 2024-05-31
Abstract Views: 18
Views PDF (Tiếng Việt): 24
DOI: https://doi.org/10.52852/tcncyh.v177i4E14.2423
Issue
Vol. 177 No. 4E14 (2024)
Section
Các bài báo
How to Cite
Oanh, L. H., Chau, H. M., Manh, K. V., Thuong, P. T., Duong, D. T., Trang, T. Q., Anh, P. T. V., Hang, D. T. T., & Thuy, N. T. (2024). 19. Evaluation of subchronic toxicity of diabetna capsules in experimental animals. Journal of Medical Research, 177(4E14), 149-157. https://doi.org/10.52852/tcncyh.v177i4E14.2423

19. Evaluation of subchronic toxicity of diabetna capsules in experimental animals

Le Hong Oanh, Hoang Minh Chau, Khuat Van Manh, Phuong Thien Thuong, Dau Thuy Duong, Tran Quynh Trang, Pham Thi Van Anh, Dinh Thi Thu Hang, Nguyen Thi Thuy

Main Article Content

Abstract

This research aimed to evaluate the subchronic toxicity of Diabetna capsules through oral administration in experimental animals. The subchronic toxicity was studied in Wistar rats with oral doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16 g/kg/day (3 times as high as recommended human dose) in consecutive 12 weeks, following guidance from the World Health Organization and Organisation for Economic Co-operation and Development. Our result showed that Diabetna capsules had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and microscopic images of the livers and kidneys of Wistar rats. In conclusion, Diabetna capsules did not produce subchronic toxicity in experimental animals.

Article Details

Keywords

Diabetna capsules, subchronic toxicity, Wistar rats

References

1. De Jong WH, Carraway JW, Geertsma RE. In vivo and in vitro testing for the biological safety evaluation of biomaterials and medical devices. Biocompatibility and Performance of Medical Devices. 2012; 120-158.
2. Saganuwan SA. Toxicity studies of drugs and chemicals in animals: An overview. Bulgarian Journal of Veterinary Medicine. 2017; 20(4):291-318.
3. Venkatasubbu GD, Ramasamy S, Gaddam PR, et al. Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles. International Journal of Nanomedicine. 2015; 10: 137-148
4. Salmerón-Manzano E, Garrido-Cardenas JA, Manzano-Agugliaro F. Worldwide Research Trends on Medicinal Plants. Int J Environ Res Public Health. 2020 May 12; 17(10): 3376.
5. Đỗ Tất Lợi (2015). Những cây thuốc và vị thuốc Việt Nam. Nhà xuất bản Y học, Hà Nội.
6. World Health Organization. Working group on the safety and efficacy of herbal medicine, Report of regional office for the western pacific of the World Health Organization, 2000.
7. Jitareanu A., Trifan A., Vieriu M., et al. Current Trends in Toxicity Assessment of Herbal Medicines: A Narrative Review. Processes. 2022; 11(1): 83.
8. Olson H, Betton G, Robinson D, et al. Concordance of the toxicity of pharmaceuticals in humans and in animals.Regulatory Toxicology and Pharmacology. 2000; 32(1): 56–67.
9. OECD. Guidelines for the testing of chemicals repeated dose oral toxicity study in rodents. Environmental Health and Safety Monograph Series on Testing and Assesment No 407. 2008
10. Raji RO, Muhammad HL, Abubakar A, et al. Acute and sub-acute toxicity profile of crude extract and fractions of Gymnema sylvestre. Clin Phytosci. 2021; 7, 56 (2021).
11. Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014;2014:830285.