31. Investigation of extract from jasminum subtriplinerve blume leaves for acute and subchronic oral toxicity in experimental animals
Main Article Content
Abstract
This research is conducted to evaluate the acute and subchronic toxicities of the extract of Jasminum subtriplinvere Blume leaves through oral administration in experimental animals. The acute toxicity was determined by the Litchfield Wilcoxon method in Swiss mice. The subchronic toxicity was evaluated by WHO and OECD’s recommendation in Wistar rats with oral doses of 2.4 g/kg/day and 7.2 g/kg/day for 90 consecutive days. We found no sign of toxicity and no mortality was observed in Jasminum subtriplinvere Blume treated mice at 5000 mg/kg. In terms of the subchronic toxicity test, after oral administration of the extract of Jasminum subtriplinvere Blume, hematological parameters, hepato-renal functions, and microscopic images of the liver and kidney were unchanged as compared with the control group. In conclusion, the extract of Jasminum subtriplinvere Blume leaves did not produce acute and subchronic toxicities in Swiss mice and Wistar rats.
Article Details
Keywords
Jasminum subtriplinvere Blume, acute toxicity, subchronic toxicity, experimental animals
References
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2. Organization. WH. WHO global report on traditional and complementary medicine. 2019.
3. Venkatasubbu GD, Ramasamy S, Gaddam PR, Kumar J. Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles. Int J Nanomedicine. 2015; 10 Suppl 1(Suppl 1): 137-48. doi:10.2147/ijn.S79991.
4. Jong WH, Carraway J, Re G. In vivo and in vitro testing for the biological safety evaluation of biomaterials and medical devices. Biocompatibility and Performance of Medical Devices. 10/01 2012: 120-158. doi:10.1016/B978-0-85709-070-6.50007-9.
5. Alhaji Saganuwan S. Toxicity studies of drugs and chemicals in animals: An overview. Bulgarian Journal of Veterinary Medicine. 12/01 2017; 20:291-318. doi:10.15547/bjvm.983.
6. Ngan DH, Hoai HT, Huong le M, Hansen PE, Vang O. Bioactivities and chemical constituents of a Vietnamese medicinal plant Che Vang, Jasminum subtriplinerve Blume (Oleaceae). Nat Prod Res. 2008; 22(11): 942-9. doi:10.1080/14786410701647119.
7. Bich D, Chung D, Chuong B, et al. The medicinal plants and animals in Vietnam. Hanoi Sci Technol Publ House Hanoi. 01/01 2004; 1.
8. Health. Mo. Vietnamese Pharmacopoeia 5th, 2, Medical Publishing House, Hanoi, 1109. 2018;
9. L. DT. Medicinal plants and remedies of Vietnam, Publisher of Medicine, Hanoi, 121-122. 2004;
10. B. DTNaLTT. Initially studying the chemical composition and biological activities of the Jasminum subtriptinerve, Journal of Pharmacology, 6, 16-18. 1984;
11. Nguyen T. D. H. PHS, Bui D. T. H., Ho T. C. H. and Nguyen T. T. M. Bioactivities and chemical constituents of a Vietnamese medicinal plant vang se Jasminum subtriplinerve Blume, Journal of Science and Technology Development, 15(3), 37-44. 2012.
12. S. VTN. Antibiotic effect of Jasminum subtriplinerve, Journal of Pharmacology, 2, 18-21. 1984.
13. S. PH. Chemical investigation of fractions with hepatoprotective effects of Jasminum subtriplinerve, Master’s thesis in chemistry, Vietnam National University, Ho Chi Minh City, University of Natural Sciences, 62-63. 2012.
14. N. NTNHaDT. Pharmacological effects of Jasminum subtriptinerve preparations, Journal of Pharmacology, 1, 17-18. 1985.
15. Hong Minh P, Phuong Thanh M, Thi Thu Trang T, My Dung H. Assessment of Semi-chronic Toxicity and Lipid-lowering Effect of Jasminum subtriplinerve Blume Oleaceae Extract. VNU Journal of Science: Medical and Pharmaceutical Sciences. 2023-03-25 2023; 39(1). doi: 10.25073/2588-1132/vnumps.4409.
16. Organization WH. General guidelines for methodologies on research and evaluation of traditional medicine 12 November 2000. 2000.
17. OECD. Test No. 423: Acute Oral toxicity - Acute Toxic Class Method. 2002.
18. OECD. Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents. 2018.
19. Nguyen Tra My NTT, Nguyen Thi Ha Ly, Vu Thi Diep, Tran Huyen Trang, Pham Thi Hien, Hoang Thi Dieu Huong, Nguyen Thi Thuy, Nguyen Minh Khoi, Do Thi Ha. Chemical Constituents from Twigs and Leaves of Jasminum subtriplinerve Blume. Journal of Medicinal Materials. 2023; 28(06): 351 - 357.
20. Henn JG, Steffens L, de Moura Sperotto ND, et al. Toxicological evaluation of a standardized hydroethanolic extract from leaves of Plantago australis and its major compound, verbascoside. J Ethnopharmacol. Jan 30 2019; 229:145-156. doi:10.1016/j.jep.2018.10.003.
21. Lee MY, Seo CS, Cha SW, Shin HK. Safety assessment of So‑cheong‑ryong‑tang: Subchronic toxicity study in Crl:CD Sprague Dawley rats. Mol Med Rep. 2014/06/01 2014; 9(6): 2273-2282. doi:10.3892/mmr.2014.2114.
22. Organization. WH. Working group on the safety and efficacy of herbal medicine. Report of regional office for the western pacific of the World Health Organization. 2000.
23. OECD. Guidelines for the testing of chemicals repeated dose oral toxicity study in rodents. Environmental Health and Safety Monograph Series on Testing and Assesment No 407. 2008.
24. Olson H, Betton G, Robinson D, et al. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul Toxicol Pharmacol. Aug 2000; 32(1): 56-67. doi:10.1006/rtph.2000.1399.
25. Kunhachan P, Banchonglikitkul C, Kajsongkram T, Khayungarnnawee A, Leelamanit W. Chemical Composition, Toxicity and Vasodilatation Effect of the Flowers Extract of Jasminum sambac (L.) Ait. “G. Duke of Tuscany”. Evid Based Complement Alternat Med. 2012; 2012:471312. doi:10.1155/2012/471312.
26. Budin SB, Siti Nor Ain SM, Omar B, Taib IS, Hidayatulfathi O. Acute and subacute oral toxicity of Litsea elliptica Blume essential oil in rats. J Zhejiang Univ Sci B. Oct 2012; 13(10): 783-90. doi:10.1631/jzus.B1100021.
27. Tuoi Thi Hong Do QNT, Tinh Quoc Vo, Oanh Thi Kim Nguyen, Tuyen Le Thanh Nguyen. Study on the analgesic, anti-inflammatory and hypouricemic effects of 50% ethanolic extract from Jasminum subtriplinerve Blume. 2022; 6(2).