Ung thư biểu mô tế bào gan dạng Sarcom: Báo cáo ca lâm sàng

Abstract

Hepatic sarcomatoid carcinoma (HSC) is a malignant tumor containing malignant epithelial (including hepatocellular carcinoma and cholangiocellular carcinoma) and mesenchymal elements. It is extremely rare in adults and only less than 50 cases of HSC have been reported up to date, with various descriptions of clinical and imaging features. We reported a 45-year-old male with a medical history of hepatitis B, presenting with infrequent abdominal pain for three months. Abdominal ultrasound and computer tomography revealed a large tumor in the right lobe with irregular margin, hemorrhagic and central necrosis. The tumor was peripheral enhanced and invaded into adjacent portal vein. The α fetoprotein level was elevated. The patient underwent right hepatectomy and diagnosed of primary hepatic sarcomatoid carcinoma by immunohistochemistry. At one month follow-up, abdominal ultrasound detected a heterogeneous hypoechoic lesion at the left hepatic lobe, suggestive of recurrence. HSC is an aggressive tumor type with a poor prognosis and a prompt diagnosis using histological and immunohistochemical analysis is required.