14. Expression level of miR-125b in glioma patients
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Abstract
Glioma is malignant tumor originating from the brain parenchyma. Early diagnosis and targeted treatment are still a problem for modern medicine. Many studies have demonstrated that miRNAs are important in the pathogenesis of glioma, in which miR-125b acts as an oncogene with the highest expression level in brain tissue, promising to become an effective biological marker in diagnosis and treatment. This study aimed to evaluate the expression level of miR-125b in plasma of 62 glioma patients and 62 healthy controls. The results showed that the level of expression of miR-125b was significantly lower in the glioma group (0.77 ± 1.318) compared to the control group (1.165 ± 1.404) (p < 0.001) and in the group of patients under 50 years old (0.318 ± 0.312) compared to the group over 50 years old (1.143 ± 1.678) (p = 0.01). Our data suggests the relation between reduced levels of miR-125b expression and glioma and patient age.
Article Details
Keywords
Glioma, miR-125b, Realtime - PCR
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