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Published: 2024-09-11
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DOI: https://doi.org/10.52852/tcncyh.v180i7.2516
Issue
Vol. 180 No. 7 (2024)
Section
Các bài báo
How to Cite
Minh Anh, N. ., Kiên, N. T. ., & Đức, P. H. . (2024). 42. “Lollipop” sign of hepatic epithelioid hemangioendothelioma: A case series. Journal of Medical Research, 180(7), 372-378. https://doi.org/10.52852/tcncyh.v180i7.2516

42. “Lollipop” sign of hepatic epithelioid hemangioendothelioma: A case series

Nguyen Minh Anh, Nguyen Trung Kien, Pham Hong Duc

Main Article Content

Abstract

Epithelioid hemangioendothelioma (HEHE) is a rare hepatic neoplasm that poses significant diagnostic challenges due to its imaging similarities with other liver tumors. This report aims to elucidate the distinctive radiological features of HEHE using three illustrative cases. On MRI or CT with contrast enhancement during the venous phase, HEHE typically presents as multifocal liver lesions exhibiting peripheral enhancement. A notable diagnostic indicator is the “lollipop” sign, characterized by a non-enhancing tumor mass (representing the candy) and an adjacent truncated, enhancing vein (representing the stick). This sign is crucial for radiologists to identify when evaluating potential HEHE. This imaging feature can also aid pathologists in the histopathological confirmation of HEHE.

Article Details

Keywords

Hepatic epithelioid hemangioendothelioma, HEHE, rare hepatic tumors, MSCT, MRI

References

1. Kou K, Chen YG, Zhou JP, et al. Hepatic epithelioid hemangioendothelioma: Update on diagnosis and therapy. World J Clin Cases. 2020 Sep 26;8(18):3978-3987. doi: 10.12998/wjcc.v8.i18.3978.
2. Van Rosmalen BV, Verheij J, Phoa SSKS, et al. Hepatic epithelioid haemangioendothelioma (HEHE): a diagnostic dilemma between haemangioma and angiosarcoma. BMJ Case Rep. 2017 Nov 3;2017:bcr2017220687. doi: 10.1136/bcr-2017-220687.
3. Mehrabi A, Kashfi A, Fonouni H, et al. Primary malignant hepatic epithelioid hemangioendothelioma: a comprehensive review of the literature with emphasis on the surgical therapy. Cancer. 2006 Nov 1;107(9):2108-21. doi: 10.1002/cncr.22225.
4. Antonescu C. Malignant vascular tumors-an update. Mod Pathol. 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. 
5. Makhlouf HR, Ishak KG, Goodman ZD. Epithelioid hemangioendothelioma of the liver: a clinicopathologic study of 137 cases. Cancer. 1999 Feb 1;85(3):562-82. doi: 10.1002/(sici)1097-0142(19990201)85:3<562::aid-cncr7>3.0.co;2-t.
6. Virarkar M, Saleh M, Diab R, et al. Hepatic Hemangioendothelioma: An update. World J Gastrointest Oncol. 2020;12(3):248-266. DOI: 10.4251/wjgo.v12.i3.248
7. Epelboym Y, Engelkemier DR, Thomas-Chausse F, et al. Imaging findings in epithelioid hemangioendothelioma. Clin Imaging. 2019 Nov-Dec;58:59-65. doi: 10.1016/j.clinimag.2019.06.002.
8. Lv Peng, Lin Jiang. MRI findings of a hepatic epithelioid hemangioendothelioma. Quant Imaging Med Surg. 2012 Sep;2(3):237-8. doi: 10.3978/j.issn.2223-4292.2012.07.01.
9. Alomari AI. The lollipop sign: A new cross-sectional sign of hepatic epithelioid hemangioendothelioma. Eur J Radiol. 2006 Sep;59(3):460-4. doi: 10.1016/j.ejrad.2006.03. 022.
10. Luo L, Cai Z, Zeng S, et al. CT and MRI features of hepatic epithelioid haemangioendothelioma: a multi-institutional retrospective analysis of 15 cases and a literature review. Insights Imaging. 2023 Jan 5;14(1):2. doi: 10.1186/s13244-022-01344-y.
11. Studer LL, Selby DM. Hepatic Epithelioid Hemangioendothelioma. Arch Pathol Lab Med. 2018 Feb;142(2):263-267. doi: 10.5858/arpa.2016-0171-RS.
12. Soape MP, Verma R, Payne JD, et al. Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine. Case Rep Gastrointest Med. 2015;2015:326795. doi: 10.1155/2015/326795.
13. Mehrabi A, Kashfi A, Schemmer P, et al. Surgical treatment of primary hepatic epithelioid hemangioendothelioma. Transplantation. 2005 Sep 27;80(1 Suppl):S109-12. doi: 10.1097/01.tp.0000186904.15029.4a