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Published: 2024-09-11
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DOI: https://doi.org/10.52852/tcncyh.v180i7.2565
Issue
Vol. 180 No. 7 (2024)
Section
Các bài báo
How to Cite
Hà, V. T. ., Trung, N. V. ., Đức, N. M. ., Phượng, Đoàn T. K. ., Nhung, N. T. ., Vui, V. T. ., Minh, P. Đình ., & Huyền, N. T. . (2024). 7. Assessment of chromosomal aneuploidy in human sperm by fluorescence in situ hybridization (FISH) method. Journal of Medical Research, 180(7), 54-61. https://doi.org/10.52852/tcncyh.v180i7.2565

7. Assessment of chromosomal aneuploidy in human sperm by fluorescence in situ hybridization (FISH) method

Vu Thi Ha, Nguyen Viet Trung, Nguyen Minh Duc, Doan Thi Kim Phuong, Nguyen Thuy Nhung, Vuong Thi Vui, Pham Dinh Minh, Nguyen Thi Huyen

Main Article Content

Abstract

According to recent studies, sperm aneuploidy is a factor that can significantly affect men’s fertility, as well as the outcomes of assisted reproductive techniques. The most optimal and widely used technique for detecting sperm aneuploidy is fluorescence in situ hybridization (FISH). This study aims to assess the rate of sperm aneuploidy in males in Vietnam. We used the fluorescence in situ hybridization method to evaluate the aneuploidy of some chromosomes in 35 semen samples. The results showed that the rate of sperm aneuploidy with chromosomes 13, 18, 21 were: 0,174%, 0,161% and 0,259%, respectively. The total rate of sex chromosome aneuploidy is 0,417%. The results from 35 study samples allow for an initial description of the rate of sperm aneuploidy in Vietnamese men with potential for normal reproduction, providing reference value for future research.

Article Details

Keywords

Sperm aneuploidy, fluorescence in situ hybridization, chromosomes of sperm cell

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