32. Assessment acute and subacute toxicity of HemoShield in experimental animals
Main Article Content
Abstract
The study aimed to evaluate the acute and subacute toxicity of the HemoShield (HS) - a product of Vinh Phuc Pharmaceutical Company (VPO Pharco.) on mice and rats. Study the on the acute toxicity of the water extract on mice using the acute and subacute toxicity test methods according to the guidelines of the Ministry of Health and the OECD. Study the acute and sub acute toxicity of capsules on rats according to the instructions of the Ministry of Health. Research results show that with a dose of 5.0 g/kg of mouse body weight, no mouse died. HemoShield extract (1120.6 mg/kg mouse body weight/day) and dose 3 times the clinical dose of human (3360.7 mg/kg mouse body weight/day) for 4 consecutive weeks of taking the HS. All monitoring indicators of general condition, weight, hematopoietic function, liver function and kidney function are within normal limits, liver and kidney histopathology have no obvious differences compared to control group (p > 0.05). The number of platelets in mice taking high doses of the drug after 4 weeks decreased significantly compared to the control group but no bleeding symptom appeared in the tissues. Therefore, the HemoShield product is safe and can be used for further human studies at a dose not exceeding 171 mg/kg body weight.
Article Details
Keywords
Dengue fever, HemoShield (HS), acute toxicity, semi-chronic toxicity
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