25. Chronic kidney disease and long-term survival outcome of patients after radical nephrectomy for treatment of renal cell carcinoma
Main Article Content
Abstract
Currently, chronic kidney disease (CKD) is believed to be responsible for the poorer survival outcomes of radical nephrectomy. The study aimed to evaluate the rate of progression to CKD and its impact on survival outcomes of patients after radical nephrectomy. This is a Cohort study of 191 patients who underwent laparoscopic radical nephrectomy to treat renal cell carcinoma from 2013-2021; the postoperative follow-up occurred from 1 to 9 years. Results: 22/191 patients developed CKD (11.5%), and 169/191 patients did not have CKD (88.5%). At the end of the study, 4 patients passed away due to cancer, none of the death was related to CKD. The study showed that the rate of progression to CKD was higher in patients with a history of hypertension, diabetes, and smoking (p<0.05), but CKD did not affect patient survival outcomes.
Article Details
Keywords
Renal cell carcinoma, radical nephrectomy, chronic kidney disease, overall survival
References
2. Kim SP, Campbell SC, Gill I, et al. Collaborative review of risk benefit trade-offs between partial and radical nephrectomy in the management of anatomically complex renal masses. European urology. 2017; 72(1): 64-75.
3. Van Poppel H, Da Pozzo L, Albrecht W, et al. A prospective, randomised EORTC intergroup phase 3 study comparing the oncologic outcome of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma. European urology. 2011; 59(4): 543-552.
4. Gershman B, Thompson RH, Boorjian SA, et al. Radical versus partial nephrectomy for cT1 renal cell carcinoma. European urology. 2018; 74(6): 825-832.
5. Mir MC, Derweesh I, Porpiglia F, Zargar H, Mottrie A, Autorino R. Partial nephrectomy versus radical nephrectomy for clinical T1b and T2 renal tumors: a systematic review and meta-analysis of comparative studies. European urology. 2017; 71(4): 606-617.
6. Lane BR, Demirjian S, Derweesh IH, et al. Survival and functional stability in chronic kidney disease due to surgical removal of nephrons: importance of the new baseline glomerular filtration rate. European urology. 2015; 68(6): 996-1003.
7. Scosyrev E, Messing EM, Sylvester R, Campbell S, Van Poppel H. Renal function after nephron-sparing surgery versus radical nephrectomy: results from EORTC randomized trial 30904. European urology. 2014; 65(2): 372-377.
8. Wu J, Suk-Ouichai C, Dong W, et al. Analysis of survival for patients with chronic kidney disease primarily related to renal cancer surgery. BJU international. 2018; 121(1): 93-100.
9. Srinivas TR, Poggio ED. Do living kidney donors have CKD? Advances in chronic kidney disease. 2012; 19(4): 229-236.
10. Poggio ED, Braun WE, Davis C. The science of stewardship: due diligence for kidney donors and kidney function in living kidney donation-evaluation, determinants, and implications for outcomes. Clinical Journal of the American Society of Nephrology. 2009; 4(10): 1677-1684.
11. Jhee JH, Joo YS, Kee YK, et al. Secondhand smoke and CKD. Clinical Journal of the American Society of Nephrology. 2019; 14(4): 515-522.
12. Lee S, Kang S, Joo YS, et al. Smoking, smoking cessation, and progression of chronic kidney disease: results from KNOW-CKD study. Nicotine and Tobacco Research. 2021; 23(1): 92-98.
13. Tsai S-Y, Tseng H-F, Tan H-F, Chien Y-S, Chang C-C. End-stage renal disease in Taiwan: a case-control study. Journal of epidemiology. 2009; 19(4): 169-176.
14. Bahrey D, Gebremedhn G, Mariye T, et al. Prevalence and associated factors of chronic kidney disease among adult hypertensive patients in Tigray teaching hospitals: a cross-sectional study. BMC Research Notes. 2019; 12(1): 1-5.