37. Tác dụng chống đông của viên nang cứng Mantra 3protect Vascular Active trên thực nghiệm

Abstract

The study aimed to evaluate the anticoagulant effects of Mantra 3Protect Vascular Active (M3PV) tablets and their impact on liver damage and kidney function in a lipopolysaccharide-induced coagulation model using Swiss mice. M3PV and rivaroxaban were administered orally for seven days. One hour after the final dose, lipopolysaccharide was injected via the tail vein. Blood samples were collected four hours post-lipopolysaccharide administration to assess study parameters. Our findings indicated that M3PV at 432 mg/kg per day tended to exhibit anticoagulant effects by increasing platelet count and prolonging prothrombin time. At 1296 mg/kg per day, M3PV demonstrated anticoagulant effects by increasing platelet count, prolonging prothrombin time and activated partial thromboplastin time. Furthermore, neither dose of M3PV (432 mg/kg nor 1296 mg/kg per day) caused liver damage or affected kidney function in Swiss mice with lipopolysaccharide-induced coagulation. In summary, M3PV exhibits anticoagulant effects without compromising liver or kidney function in a mouse model of lipopolysaccharide-induced coagulation.