Prognostic value of total tumor volume for patients with stage III-IVB nasopharyngeal carcinoma after intensity-modulated radiotherapy
Main Article Content
Abstract
The study was conducted to evaluate the prognostic value of total tumor volume (TTV) in the
primary tumor and in lymph nodes for predicting survival outcomes in patients who had stage III-IVB
nasopharyngeal carcinoma (NPC) and received intensity-modulated radiotherapy concurrently with
cisplatin followed by adjuvant chemotherapy. From January 2014 to January 2020, 57 stage III-IVB NPC
patients were treated with an uncontrolled clinical intervention at 108 Central Military Hospital. In receiver
operating characteristic (ROC) curve analysis, the cut-off values of TTV for predicting locoregional
relapse-free survival (LRRFS), distant metastasis-free survival (DMFS) and progression-free survival
(PFS) were 77.8 cm3, 89.6 cm3 and 60 cm3, respectively. The 3 - year estimated rates of LRRFS, PFS
and OS were higher in patients with TTV ≤ 60 cm3 than in those with TTV > 60 cm3 (p < 0.05). The
3-year DMFS was higher in patients with TTV ≤ 89.6 cm3 than in those with TTV > 89.6 cm3 (p = 0.041).
Multivariate analysis indicated that TTV was a significant independent prognostic factor for LRRFS,
DMFS and PFS, while AJCC stage classification was not a significant independent prognostic factor.
Article Details
Keywords
Nasopharyngeal carcinoma, intensity-modulated radiotherapy, tumor volume, prognosis.
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