Effects of “Kien ty chi thong HV” remedy on Cysteamine –induced gastric-duodenal ulcer in animal
Main Article Content
Abstract
The aim of this study was to investigate the protective effect of Kien ty chi thong HV (KTHV) remedy on cysteamine-induced gastric-duodenal ulcer in experimental animals. The rats were divided into 5 groups: Group1(control) and group 2 (model) group 3 (ranitidine 50mg/kg), group 4 (KTHV 15 g/kg) and group 5 (KTHV 30 g/kg). All of rats were treated for 7 consecutive days. On day 7, rats were induced peptic-duodenal ulcers by oral cysteamine 400 mg/kg. The number of rats with ulcer, the number of ulcers per one rat and ulcer index of each group were estimated. The results showed that cysteamine caused peptic ulcer in 100% of rats. KTHV at two doses reduced the number of ulcer, the ulcer index and the level of macroscopic and microscopic damage to the stomach and duodenum improved compared to the model group. KTHV at the dose of 30 g/kg has better effect on improving gastric-duodenal ulcer than the dose of 15 g/kg when compared with model group. Conclusively, KTHV remedy had a protective effect on cysteamine-induced gastric-duodenal ulcer in experimental animals.
Article Details
Keywords
Kien ty chi thong HV, gastric-duodenal ulcer, cysteamine, experimental animal.
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