Effect of heparin treatment on plasma albumin quantification by Bromcresol Green method
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Abstract
This is a cross-sectional descriptive study evaluating the bias between two albumin quantification methods, BCG (Bromocresol Green) and BCP (Bromocresol Purple) on plasma samples of patients with or without heparin treatment. The study was conducted on 272 patient samples with or without heparin treatment to compare albumin quantification results using both BCG and and the reference method BCP which was demonstrated not to be interfered by heparin. Results of albumin concentration quantified by the BCG method was on average 15.1% higher than the BCP method (95%CI: 13.3% - 16.8%). Discrepancies in the sample of patients receiving heparin were a total of 19.35% (95%CI: 15.2% - 23.5) and 29.39% (95%CI: -34.07 - -24.71) in cases of albumin concentration < 25 g/L.
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Keywords
Bromocresol Green, BCG, Bromocresol Purple, BCP
References
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