Effects of guava leaf (Psidii guajavae folium) on serum lipid profiles in dyslipidemia experimental animals
Main Article Content
Abstract
The study evaluated the lipid-lowering effect of guava leaf extract in the endogenous and exogenous dyslipidemia models. In the endogenous dyslipidemia model, Swiss mice were intraperitoneally injected with poloxamer 407 at a single dose of 200 mg/kg. The exogenous dyslipidemia model was induced in Wistar rats by orally administrating an oil-cholesterol mixture for 4 consecutive weeks. The lipid-lowering activities were evaluated based on changes in serum lipid concentrations. The guava leaf extract (150 and 300 mg/kg) dramatically decreased TC and LDL-C following four weeks of administration in the exogenous model. The endogenous model showed a significant reduction in TG, TC, and non-HDL-C concentrations upon pre-treatment of guava leaf extract at dosages of 300 mg/kg and 600 mg/kg for 7 consecutive days. In conclusion, the anti-hyperlipidemic activities of the guava leaf extract were demonstrated by lowering the levels of TC, TG, LDL-C, and non-HDL-C in the experimental animals.
Article Details
Keywords
guava leaf, dyslipidemia, poloxamer 407
References
2. Bộ Y tế. Hướng dẫn Chẩn đoán và điều trị bệnh Nội tiết - chuyển hóa. Nhà xuất bản Y học. 2015:256- 263.
3. Berberich AJ, Hegele RA. A Modern Approach to Dyslipidemia. Endocrine reviews. 2022;43(4):611-653. doi:10.1210/endrev/bnab0 37
4. Đỗ Tất Lợi. Ổi (lá). Những cây thuốc và vị thuốc Việt Nam. Nhà xuất bản Y học; 2004:431-432.
5. Đỗ Huy Bích, Đặng Quang Chung, Bùi Xuân Chương, và cs. Ổi. Cây thuốc và động vật làm thuốc ở Việt Nam. Nhà xuất bản Khoa học và kỹ thuật; 2006:500-504.
6. Phan Hồng Minh, Đỗ Thị Hồng Khánh, Lê Anh Tuấn, và cs. Tác dụng hạ glucose máu của cao chiết lá ổi trên chuột nhắt trắng bị đái tháo đường týp 2. Tạp chí Nghiên cứu Y học. 2024;176(3):153-162. doi:10.52852/tcncyh.v17 6i3.2305
7. Tella T, Masola B, Mukaratirwa S. Anti-diabetic potential of Psidium guajava leaf in streptozotocin induced diabetic rats. Phytomedicine Plus. 2022/05/01/ 2022;2(2):100254. doi: 10.1016/j.phyplu.2022. 100254
8. Gutiérrez RM, Mitchell S, Solis RV. Psidium guajava: a review of its traditional uses, phytochemistry and pharmacology. Journal of ethnopharmacology. 2008;117(1):1-27.
9. Abd El-Wahab HMF, Galal SM, Abd El-Razik FH, et al. Anti-hyperlipidemic and Anti-hypercholesterolemic effect of aqueous extract of guava (Pisidum guajava Linn.) leaves on rats. Journal of Scientific Research in Science. 2016;33(part1):565-584.
10. Deguchi Y, Miyazaki K. Anti-hyperglycemic and anti-hyperlipidemic effects of guava leaf extract. Nutrition & metabolism. Feb 2 2010;7:9. doi:10.1186/1743-7075-7-9
11. Olaniyan MF. Cholesterol lowering effect of guava leaves (Psidium guajava) extract on egg yolk induced hypercholesterolaemic rabbits. Journal of Biology. 2017;7(1):24-27.
12. Nassiri-Asl M, Zamansoltani F, Abbasi E, et al. Effects of Urtica dioica extract on lipid profile in hypercholesterolemic rats. Zhong Xi Yi Jie He Xue Bao. 2009;7(5):428-433.
13. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical chemistry. 1972;18(6):499-502.
14. Leon C, Wasan KM, Sachs-Barrable K, et al. Acute P-407 administration to mice causes hypercholesterolemia by inducing cholesterolgenesis and down-regulating low-density lipoprotein receptor expression. Pharm Res. 2006;23(7):1597-1607.
15. Karimi I. Animal Models as Tools for Translational Research: Focus on Atherosclerosis, Metabolic Syndrome and Type-II Diabetes Mellitus. InTech. 2012. Available at: http://dx.doi.org/10.5772/47769.
16. Vijayakumar K, Rengarajan RL, Radhakrishnan R, et al. Hypolipidemic Effect of Psidium guajava Leaf Extract Against Hepatotoxicity in Rats. Pharmacognosy magazine. 2018;14(53):4-8. doi:10.4103/pm.p m_167_17
17. Alam MA, Kauter K, Brown L. Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats. Nutrients. 2013;5(3):637-650. doi:10.3390/nu5030637
18. Mamun MAA, Faruk M, Rahman MM, et al. High carbohydrate high fat diet induced hepatic steatosis and dyslipidemia were ameliorated by Psidium guajava leaf powder supplementation in rats. Evidence-Based Complementary. 2019;2019(1):1897237. doi: 10.1155/2019/1897237.
19. Vinarova L, Vinarov Z, Atanasov V, et al. Lowering of cholesterol bioaccessibility and serum concentrations by saponins: in vitro and in vivo studies. Food Funct. 2015;6(2):501-512. doi:10.1039/c4fo00785a