Effects of TD0015 pills on blood biochemistry values and histology of liver and kidney in Wistar rats
Main Article Content
Abstract
TD0015 pills contain medicinal herbs recognized for their anti-inflammatory, pain-relieving, and inhibitory effects on joint cartilage destruction, enhancing cartilage structure in osteoarthritis. This product was developed for the oral treatment of osteoarthritis symptoms. The study aimed to investigate the impact of TD0015 pills on liver and kidney function, as well as liver and kidney histopathology in rats. The animals received either water or TD0015 pills at 1.2 g/kg and 3.6 g/kg for 90 consecutive days. The results indicated that both doses of TD0015 administered over 90 consecutive days showed no harmful effect on liver function (including protein metabolism and bile secretion), AST and ALT enzyme levels, kidney function (creatinine levels), or liver and kidney histopathology in rats. Total cholesterol levels decreased within the allowable value limit without affecting the general condition of the mice.
Article Details
Keywords
TD0015 pills, sub-chronic toxicity, Wistar rats
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