39. Prognostic value of AST/ALT, APRI and FIB-4 in patients with chronic hepatitis B
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Abstract
This cross-sectional descriptive study on 199 patients diagnosed with chronic hepatitis and treated at Vinh Phuc General Hospital was conducted to evaluate the prognostic value of AST/ALT ratio, AST-to-Platelets Ratio Index (APRI), and fibrosis-4 (FIB-4) in patients with chronic hepatitis B. The results showed that the AST/ALT ratio, FIB-4, and APRI could fairly predict the degree of liver fibrosis with Child-Pugh C with area under the curves of ROC (AUC) values of 0.757, 0.786, and 0.799, respectively. The ability of AST/ALT and FIB-4 to predict mortality after 6 months in chronic hepatitis B patients was low, whereas the APRI showed a moderate predictive value with an AUC of 0.707. APRI ≥ 2.02 was determined as a threshold for predicting patient mortality, with sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of 33.3%, 82.1%, 79.9%, 8.1%, and 96.3%, respectively.
Article Details
Keywords
Chronic hepatitis B, AST/ALT, APRI, FIB-4, cirrhosis, Child-Pugh
References
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