Antioxidant effect of Ich tri vuong capsule on carotid atherosclerosis patients
Main Article Content
Abstract
Ich Tri Vuong capsule components are Ginkgo biloba, Radix Salviae miltiorrhi zae, Radix Astragali membranacei and Radix Angelicae sinensis. The studies designed to accessing effect of Ich Tri Vuong capsule on Total antioxidant status (TAS), Superoxid dismustase (SOD) and Malondialdehyde (MDA) in blood on carotid atherosclerosis patients with low-grade carotid stenosis. The randomized clinical trial studied 60 carotid atherosclerosis patients, divided into two groups. Ich Tri Vuong group included 30 patients taking 4 pills of Ich tri vuong per day for 8 weeks. Atorvastatin group included 30 patients taking atorvastatin at 10 mg/day for 8 weeks. Results suggested that Ich Tri Vuong had the effect of increasing TAS serum level (0.15 ± 0.23 mmol/L), decreasing activity of SOD in red blood cells level (-133.62 ± 251.20 U/gHb), suppressing the increase of the MDA serum level.
Article Details
Keywords
Ich Tri Vuong, carotid therosclerosis, antioxidant
References
2. Zaric BL, Macvanin MT, Isenovic ER. Free radicals: Relationship to Human Diseases and Potential Therapeutic applications. Int J Biochem Cell Biol. 2023;154:106346. doi:10.1016/j.biocel.2022.106346
3. Bir S, Kelley R. Carotid atherosclerotic disease: A systematic review of pathogenesis and management. Brain Circ. 2022;8(3):127. doi:10.4103/bc.bc_36_22.
4. Flieger J, Flieger W, Baj J, et al. Antioxidants: Classification, Natural Sources, Activity/Capacity Measurements, and Usefulness for the Synthesis of Nanoparticles. Materials. 2021;14(15):4135. doi:10.3390/ma1 4154135.
5. Sezer E, Sozmen, Nart, et al. Effect of atorvastatin therapy on oxidant-antioxidant status and atherosclerotic plaque formation. Vasc Health Risk Manag. Published online June 2011:333. doi:10.2147/VHRM.S17781.
6. Song L, Zhang J, Lai R, et al. Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis. Front Pharmacol. 2021;12. doi:10.3389/fphar.2021.675999.
7. Zhang M, Geng W, Guan X, et al. Antioxidant and anti-inflammatory effects of different ratios and preparations of Angelica sinensis and chuanxiong rhizoma extracts. J Ethnopharmacol. 2024;334:118559. doi:10.10 16/j.jep.2024.118559
8. Adesso S, Russo R, Quaroni A, et al. Astragalus membranaceus Extract Attenuates Inflammation and Oxidative Stress in Intestinal Epithelial Cells via NF-κB Activation and Nrf2 Response. Int J Mol Sci. 2018;19(3):800. doi:10.3390/ijms19030800
9. Zhang H, Chen S, Deng X, et al. The effects of Danggui-Buxue-Tang on blood lipid and expression of genes related to foam cell formation in the early stage of atherosclerosis in diabetic GK rats. Diabetes Res Clin Pract. 2007;77(3):479-481. doi:10.1016/j.diabres.200 6.11.005
10. Lê Thị Minh Phương, Đỗ Thị Phương, Nguyễn Trần Thị Giáng Hương. Tác dụng chống oxy hóa của viên nang mềm Ích trí vương trên thỏ gây xơ vữa động mạch bằng chế độ ăn giàu cholesterol. Tạp chí Y Dược học cổ truyền Quân sự. 2018;8(2):55-65.
11. Lê Thị Minh Phương, Trần Việt Hùng, Đỗ Thị Phương, và cs. Nghiên cứu ảnh hưởng của viên nang mềm bào chế từ bài Đương quy bổ huyết gia phương trên người khỏe mạnh qua một số chỉ tiêu lâm sàng và cận lâm sàng. Tạp chí Dược học. 2017;496(8):77-80.
12. Zhou D, Meng R, Li S, et al. Advances in chronic cerebral circulation insufficiency. CNS Neurosci Ther. 2018;24(1):5-17. doi:10.1111/cn s.12780.
13. Hobson RW, Mackey WC, Ascher E, et al. Management of atherosclerotic carotid artery disease: Clinical practice guidelines of the Society for Vascular Surgery. J Vasc Surg. 2008;48(2):480-486. doi:10.1016/j.jvs.20 08.05.036
14. Jebari-Benslaiman S, Galicia-García U, Larrea-Sebal A, et al. Pathophysiology of Atherosclerosis. Int J Mol Sci. 2022;23(6):3346. doi:10.3390/ijms23063346
15. Srinivasa Rao PVLN, Kiranmayi VS, Swathi P, et al. Comparison Of Two Analytical Methods Used For The Measurement Of Total Antioxidant Status. Journal of Antioxidant Activity. 2015;1(1):22-28. doi:10.14302/issn.24 71-2140.jaa-14-617.