Acute toxicity and effects of TD0015 on body weight and some hematological parameters of experimental animals
Main Article Content
Abstract
TD0015 pills contain ingredients that have displayed analgesic, anti-inflammatory properties and can inhibit articular cartilage destruction. Therefore, it has been developed to manage bone and joint conditions. This study aimed to evaluate the oral acute toxicity and sub-chronic toxicity focusing on the impacts of TD0015 on body weight and hematopoietic function in experimental animals. The acute toxicity was conducted in Swiss mice to determine the lethal dose 50 (LD50) using the Litchfield-Wilcoxon method. The sub-chronic toxicity study was conducted in Wistar rats orally administered TD0015 at two doses: 1.2 g/kg/day and 3.6 g/kg/day for 90 days consecutively. Our findings indicated that TD0015 has the maximal tolerated dose of 37.5 g/kg/day, causing no acute toxicity. The LD50 of TD0015 has not been determined. Additionally, after 90 days, TD0015 pills at both doses did not affect the general condition, body weight and hematological indicators in mice.
Article Details
Keywords
TD0015, acute toxicity, body weight, hematopoietic function, experimental animals
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